SCHEMBL11023978

SCHEMBL11023978

CCCCCN1CC(=O)NC(=O)C1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C19 P33261 1/20 0.47
PTGS1 P23219 5/20 0.44
TOP2A P11388 2/20 0.44
TOP2B Q02880 2/20 0.44
LMNA P02545 1/20 0.44
ALOX5 P09917 2/20 0.43
CRBN Q96SW2 1/20 0.41
GNAI3 P08754 4/20 0.40
GNAO1 P09471 4/20 0.40
GNAI1 P63096 4/20 0.40
PTGS2 P35354 3/20 0.39
MGLL Q99685 3/20 0.39
FAAH O00519 2/20 0.39
MAPT P10636 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
GAA P10253 1/20 0.38
THRB P10828 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11383117 0.94 PTGS1 (0.46) ALDH1A1CYP1A2CYP2D6CYP2C19PTGS1
SCHEMBL5707893 0.85 TOP2A (0.48) ALDH1A1CYP2C19PTGS1TOP2ATOP2B
SCHEMBL9752550 0.84 TOP2A (0.47) ALDH1A1CYP2C19PTGS1TOP2ATOP2B
SCHEMBL9229895 0.80 ALDH1A1 (0.52) ALDH1A1CYP1A2CYP2D6CYP2C19PTGS1
SCHEMBL8029443 0.80 ALOX5 (0.41) ALDH1A1CYP1A2CYP2D6CYP2C19PTGS1
SCHEMBL728996 0.79 TOP2A (0.50) ALDH1A1CYP2C19PTGS1TOP2ATOP2B
SCHEMBL461664 0.78 CRBN (0.45) ALDH1A1CYP1A2CYP2D6CYP2C19PTGS1
SCHEMBL974631 0.77 THRB (0.51) ALOX5GNAI3GNAO1GNAI1THRB
SCHEMBL162839 0.76 ALOX5 (0.45) ALDH1A1CYP1A2CYP2D6CYP2C19PTGS1
SCHEMBL6233217 0.76 ALOX5 (0.45) ALDH1A1CYP1A2CYP2D6CYP2C19PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0086678-B1 PROCESS FOR THE PREPARATION OF 2-ACYL-1,3,4,6,7,11B-2H-HEXAHYDRO-4-PYRAZINO(2,1-A)ISOQUINOLINONES AND INTERMEDIATES ELF SANOFI (FR) 1985-07-03 EP claimed
US-4523013-A 4-Acyl-2,6-dioxo-1-phenethyl piperozines SANOFI, S.A. (FR) 1985-06-11 US disclosed
US-4523013-A 4-Acyl-2,6-dioxo-1-phenethyl piperozines SANOFI, S.A. (FR) 1985-06-11 US disclosed