Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 15/20 | 0.51 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18634073 | 0.98 | THRB (0.53) | THRBGNAI3GNAO1GNAI1ALOX5 | |
| SCHEMBL9029619 | 0.95 | THRB (0.49) | THRB | |
| Hydrochloric Acid SCHEMBL9029064 | 0.93 | THRB (0.48) | THRBGNAI3GNAO1GNAI1 | |
| Propene SCHEMBL4084262 | 0.92 | THRB (0.47) | THRBGNAI3GNAO1GNAI1ALOX5 | |
| SCHEMBL257071 | 0.87 | THRB (0.45) | THRB | |
| SCHEMBL5704250 | 0.84 | THRB (0.42) | THRBALOX5 | |
| SCHEMBL13178226 | 0.84 | ALOX5 (0.45) | THRBGNAI3GNAO1GNAI1ALOX5 | |
| SCHEMBL30902677 | 0.81 | CXCR4 (0.50) | THRB | |
| SCHEMBL30902672 | 0.81 | CXCR4 (0.50) | THRB | |
| SCHEMBL4490796 | 0.81 | SMN1; SMN2 (0.39) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680270-B2 | Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties | VIAMET PHARMACEUTICALS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| EP-2086546-B1 | METALLO-OXIDOREDUCTASE INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES | VIAMET PHARMACEUTICALS INC (US) | 2013-07-10 | — | — | EP | disclosed |
| EP-2543368-A1 | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties | Viamet Pharmaceuticals, Inc. (US) | 2013-01-09 | — | — | EP | disclosed |
| US-20110015158-A1 | METALLOENZYME INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES | VIAMET PHARMACEUTICALS, INC. (US) | 2011-01-20 | — | — | US | disclosed |
| US-20100311749-A1 | 4-BENZOYL-1-SUBSTITUTED-PIPERAZIN-2-ONE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-12-09 | — | — | US | disclosed |
| US-20100305078-A1 | METALLO-OXIDOREDUCTASE INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES | VIAMET PHARMACEUTICALS, INC. (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100256082-A1 | Metallo-hydrolase inhibitors using metal binding moietes in combination with targeting moieties | VIAMET PHARMACEUTICALS, INC. (US) | 2010-10-07 | — | — | US | disclosed |
| EP-2234608-A2 | METALLOENZYME INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES | Viamet Pharmaceuticals, Inc. (US) | 2010-10-06 | — | — | EP | disclosed |
| EP-2212300-A1 | 4-BENZ0YL-1-SUBSTITUTED-PIPERAZIN-2-0NE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2010-08-04 | — | — | EP | disclosed |
| US-7632833-B2 | Anticancer agents | MERCK & CO., INC. (US) | 2009-12-15 | — | — | US | disclosed |
| WO-2008064311-A2 | METALLO-OXIDOREDUCTASE INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES | VIAMET PHARMACEUTICALS, INC. (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008036445-A2 | METALLO-HYDROLASE INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES | VIAMET PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| US-20050113514-A1 | 4-N-acyl-delta 5-2-oxopiperazines, a process for its preparation and combinatorial libraries thereof | CHENG JIE F (US) | 2005-05-26 | — | — | US | disclosed |
| EP-0924248-B1 | Stabilization of polycarbonate/ABS blends with mixtures of hindered amines and UV absorbers | CIBA SC HOLDING AG (CH) | 2004-04-28 | — | — | EP | disclosed |
| US-5990208-A | BLEND OF POLYCARBONATE AND POLYESTERS, STYRENIC COPOLYMERS, RUBBERS OR VINYL CHLORIDE CO- OR HOMOPOLYMERS, 1,3,5-TRIS(N-CYCLOHEXYL-N-(2-(3,3,4,5,5-PENTAMETHYLPIPERAZINE-2-ON-1-YL)-ET HYL)AMINO-S-TRIAZINE AND UV ABSORBER; AUTOMOBILES | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0924248-A1 | Stabilization of polycarbonate/ABS blends with mixtures of hindered amines and UV absorbers | Ciba SC Holding AG (CH) | 1999-06-23 | — | — | EP | disclosed |
| US-4753979-A | SUBSTITUTED 4-ACYL-2-PIPERAZINONES; FOR POLYOLEFINS OR ACRYLIC OR ALKYD RESINS | CIBA-GEIGY CORPORATION (US) | 1988-06-28 | — | — | US | disclosed |
| US-4753979-A | SUBSTITUTED 4-ACYL-2-PIPERAZINONES; FOR POLYOLEFINS OR ACRYLIC OR ALKYD RESINS | CIBA-GEIGY CORPORATION (US) | 1988-06-28 | — | — | US | disclosed |
| US-4650870-A | AUTOMOBILE PAINTS | CIBA-GEIGY CORPORATION (US) | 1987-03-17 | — | — | US | disclosed |
| US-4650870-A | AUTOMOBILE PAINTS | CIBA-GEIGY CORPORATION (US) | 1987-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015158-A1 | METALLOENZYME INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES | GAA, GBA3, HMBS | THRB 2497/4885GNAI3 2660/4885GNAO1 2649/4885 |
| US-20100256082-A1 | Metallo-hydrolase inhibitors using metal binding moietes in combination with targeting moieties | MMEL1, MPI, METAP1 | THRB 2891/4885GNAI3 3486/4885GNAO1 2985/4885 |
| US-20100305078-A1 | METALLO-OXIDOREDUCTASE INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES | NQO1, SOD1, MDH2 | THRB 3167/4885GNAI3 2727/4885GNAO1 1801/4885 |
| US-20100311749-A1 | 4-BENZOYL-1-SUBSTITUTED-PIPERAZIN-2-ONE DERIVATIVES AS P2X7 MODULATORS | P2RX7, P2RX3, P2RX2 | THRB 1385/4885GNAI3 1925/4885GNAO1 1367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.