Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL392238 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL11029441 | 0.73 | ADRA2A (0.33) | ADRA2AADRA2BADRA2CGABRA1GABRB2 | |
| SCHEMBL10790494 | 0.70 | GABRA1 (0.44) | ADRA2AADRA2BADRA2CGABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL3615425 | 0.70 | MEN1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL394796 | 0.70 | TSHR (0.31) | GABRA1GABRB2 | |
| SCHEMBL28307193 | 0.69 | GABRA1 (0.43) | ADRA2AADRA2BADRA2CGABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL27436289 | 0.68 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CGABRA1GABRB2 | |
| SCHEMBL5586090 | 0.67 | GABRA1 (0.41) | ADRA2AADRA2BADRA2CGABRA1GABRB2 | |
| SCHEMBL8997142 | 0.66 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CGABRA1GABRB2 | |
| SCHEMBL5547437 | 0.66 | GABRA1 (0.40) | ADRA2AADRA2BADRA2CGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9062134-B2 | Half-metallocene compounds and catalyst compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2015-06-23 | — | — | US | disclosed |
| US-20140243491-A1 | Half-Metallocene Compounds and Catalyst Compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2014-08-28 | — | — | US | disclosed |
| US-8759246-B2 | Half-metallocene compounds and catalyst compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2014-06-24 | — | — | US | disclosed |
| US-20130085060-A1 | Half-Metallocene Compounds and Catalyst Compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2013-04-04 | — | — | US | disclosed |
| US-8309748-B2 | Half-metallocene compounds and catalyst compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-11-13 | — | — | US | disclosed |
| US-20120190803-A1 | HALF-METALLOCENE COMPOUNDS AND CATALYST COMPOSITIONS | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190803-A1 | HALF-METALLOCENE COMPOUNDS AND CATALYST COMPOSITIONS | POLM, AP2M1, GSTM2 | ADRA2A 4149/4885ADRA2B 4519/4885ADRA2C 4354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.