SCHEMBL1103885

SCHEMBL1103885

N#CN1CCC(CCCO)CC1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 1/20 0.48
CTSK P43235 8/20 0.39
CTSL P07711 5/20 0.39
CTSB P07858 5/20 0.39
CTSS P25774 3/20 0.39
CTSC P53634 1/20 0.39
SLC18A3 Q16572 1/20 0.34
CHRM2 P08172 1/20 0.33
CHRM4 P08173 1/20 0.33
CHRM5 P08912 1/20 0.33
CHRM1 P11229 1/20 0.33
DRD2 P14416 1/20 0.33
CHRM3 P20309 1/20 0.33
DRD4 P21917 1/20 0.33
DRD3 P35462 1/20 0.33
USP30 Q70CQ3 6/20 0.32
AKR1C3 P42330 1/20 0.32
LTA4H P09960 1/20 0.32
CYP11B2 P19099 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14941327 0.80 CHRM2 (0.35) SLC18A3CHRM2CHRM4CHRM5CHRM1
SCHEMBL387110 0.79 GPR119 (0.56) GPR119CTSKCTSLCTSBCTSS
SCHEMBL4380852 0.77 MAOB (0.37) SLC18A3CHRM2CHRM4CHRM5CHRM1
SCHEMBL27870587 0.77 GPR119 (0.48) GPR119CTSKCTSLCTSBCTSS
SCHEMBL12367012 0.77 SLC18A3 (0.37) SLC18A3CHRM2CHRM4CHRM5CHRM1
SCHEMBL20851287 0.72 SLC18A3 (0.37) SLC18A3CHRM2CHRM4CHRM5CHRM1
SCHEMBL12284377 0.72 SLC18A3 (0.37) SLC18A3CHRM2CHRM4CHRM5CHRM1
SCHEMBL1098014 0.72 NCF1 (0.48) SLC18A3CHRM2CHRM4CHRM5CHRM1
SCHEMBL79852 0.72
SCHEMBL1543625 0.72 CYP1A2 (0.38) SLC18A3CHRM2CHRM4CHRM5CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107074838-B Compound having GPR119 agonist activity, method for preparing the same, and pharmaceutical composition comprising the same as an effective ingredient 东亚ST株式会社 2021-03-19 CN disclosed
EP-3212640-B1 COMPOUND HAVING GPR119 AGONISTIC ACTIVITY, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AS EFFECTIVE COMPONENT DONG A ST CO LTD (KR) 2019-11-06 EP disclosed
EP-3212640-B1 COMPOUND HAVING GPR119 AGONISTIC ACTIVITY, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AS EFFECTIVE COMPONENT DONG A ST CO LTD (KR) 2019-11-06 EP disclosed
US-10428055-B2 Substituted piperidines having GPR119 agonistic activity DONG-A ST CO., LTD. (KR) 2019-10-01 US disclosed
US-10428055-B2 Substituted piperidines having GPR119 agonistic activity DONG-A ST CO., LTD. (KR) 2019-10-01 US disclosed
US-20190092763-A1 COMPOUND HAVING GPR119 AGONISTIC ACTIVITY, METHOD FOR PREPARING THE SAME, AND PHARMAECUTICAL COMPOSITION INCLUDING THE SAME AS EFFECTIVE COMPONENT DONG-A ST CO., LTD. (KR) 2019-03-28 US disclosed
US-20190092763-A1 COMPOUND HAVING GPR119 AGONISTIC ACTIVITY, METHOD FOR PREPARING THE SAME, AND PHARMAECUTICAL COMPOSITION INCLUDING THE SAME AS EFFECTIVE COMPONENT DONG-A ST CO., LTD. (KR) 2019-03-28 US disclosed
EP-3212640-A1 COMPOUND HAVING GPR119 AGONISTIC ACTIVITY, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AS EFFECTIVE COMPONENT Dong-A ST Co., Ltd. (KR) 2017-09-06 EP disclosed
WO-2016068453-A1 COMPOUND HAVING GPR119 AGONISTIC ACTIVITY, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AS EFFECTIVE COMPONENT DONG-A ST CO., LTD. (KR) 2016-05-06 WO disclosed
WO-2016068453-A1 COMPOUND HAVING GPR119 AGONISTIC ACTIVITY, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AS EFFECTIVE COMPONENT DONG-A ST CO., LTD. (KR) 2016-05-06 WO disclosed
WO-2009105717-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2009-08-27 WO disclosed
WO-2009105717-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2009-08-27 WO disclosed
WO-2009038974-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2009-03-26 WO disclosed
WO-2009034388-A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS PROSIDION LIMITED (GB) 2009-03-19 WO disclosed
WO-2008097428-A2 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2008-08-14 WO disclosed
WO-2008081207-A1 PIPERIDINE GPCR AGONISTS PROSIDION LIMITED (GB) 2008-07-10 WO disclosed
WO-2008081206-A1 PIPERIDINE GPCR AGONISTS PROSIDION LIMITED (GB) 2008-07-10 WO disclosed
WO-2008081208-A1 PIPERIDINE GPCR AGONISTS PROSIDION LIMITED (GB) 2008-07-10 WO disclosed
WO-2008081204-A1 PIPERIDINE GPCR AGONISTS PROSIDION LIMITED (GB) 2008-07-10 WO disclosed
WO-2008081205-A1 PIPERIDINE GPCR AGONISTS PROSIDION LIMITED (GB) 2008-07-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10428055-B2 Substituted piperidines having GPR119 agonistic activity GPR119, GPR84, GPR88 GPR119 1/4885CTSK 1681/4885CTSL 2631/4885
US-20190092763-A1 COMPOUND HAVING GPR119 AGONISTIC ACTIVITY, METHOD FOR PREPARING THE SAME, AND PHARMAECUTICAL COMPOSITION INCLUDING THE SAME AS EFFECTIVE COMPONENT GPR119, FFAR2, GCGR GPR119 1/4885CTSK 2052/4885CTSL 2835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.