Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Aminopromazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 6/20 | 0.56 |
| ▸ | KCNH2 known ✓ | Q12809 | 6/20 | 0.56 |
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.56 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.56 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.53 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.52 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.52 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.52 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.52 |
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.52 |
| ▸ | HTR2B known ✓ | P41595 | 3/20 | 0.52 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 6/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.56 |
| ▸ | DRD3 | P35462 | 6/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminopromazine SCHEMBL11041925 | 1.00 | GFER (0.59) | GFERCHRM2HTR1ACHRM1ADRA1A | |
| Aminopromazine SCHEMBL25156 | 0.88 | CHRM2 (0.70) | GFERCHRM2HTR1ACHRM1ADRA1A | |
| Aminopromazine SCHEMBL30990818 | 0.88 | CHRM2 (0.70) | GFERCHRM2HTR1ACHRM1ADRA1A | |
| Aminopromazine SCHEMBL5307944 | 0.87 | CHRM2 (0.68) | GFERCHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL2118132 | 0.84 | CYP2D6 (0.76) | GFERCHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL3682874 | 0.84 | CYP2D6 (0.76) | GFERCHRM2HTR1ACHRM1ADRA1A | |
| Levomepromazine SCHEMBL29697036 | 0.77 | LMNA (0.82) | GFERCHRM2HTR1ACHRM1ADRA1A | |
| Levomepromazine SCHEMBL218717 | 0.77 | LMNA (0.82) | GFERCHRM2HTR1ACHRM1ADRA1A | |
| Levomepromazine SCHEMBL29727144 | 0.77 | LMNA (0.82) | GFERCHRM2HTR1ACHRM1ADRA1A | |
| Promazine SCHEMBL5060002 | 0.76 | CYP2D6 (0.76) | GFERCHRM2HTR1ACHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109152702-A | COMPOSITIONS FOR TOPICAL APPLICATION OF COMPOUNDS | 伊拉斯吹斯制药有限公司 | 2019-01-04 | — | — | CN | disclosed |
| US-4484921-A | Theophylline therapy utilizing osmotic delivery | ALZA CORPORATION (US) | 1984-11-27 | — | — | US | disclosed |
| US-4439195-A | Theophylline therapy | ALZA CORPORATION (US) | 1984-03-27 | — | — | US | disclosed |
| US-4326525-A | Osmotic device that improves delivery properties of agent in situ | ALZA CORPORATION (US) | 1982-04-27 | — | — | US | disclosed |