Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733211 | 0.79 | PTGS2 (0.59) | PTGS2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL11042737 | 0.75 | PTGS2 (0.50) | PTGS2KMT2ACYP3A4MAPTHTR2A | |
| SCHEMBL724406 | 0.75 | PTGS2 (0.59) | PTGS2MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL9483852 | 0.74 | KMT2A (0.43) | PTGS2MEN1KMT2AALDH1A1HTR2A | |
| SCHEMBL25139903 | 0.73 | CA2 (0.41) | MEN1KMT2AUSP2ALDH1A1CYP1A2 | |
| SCHEMBL9748502 | 0.72 | ALDH1A1 (0.58) | MEN1KMT2AUSP2ALDH1A1CYP1A2 | |
| SCHEMBL8337638 | 0.71 | TUBB4A (0.50) | PTGS2CYP3A4MAPTHTR2AHTR2C | |
| SCHEMBL11404883 | 0.70 | ALDH1A1 (0.46) | MEN1KMT2AUSP2ALDH1A1CYP1A2 | |
| SCHEMBL8395 | 0.70 | PTGS2 (0.53) | PTGS2MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL27548119 | 0.70 | ACHE (0.43) | PTGS2MEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |