Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | XDH | P47989 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2126131 | 1.00 | NFE2L2 (0.53) | NFE2L2XDHALDH1A1KDM4EMAPT | |
| SCHEMBL30569765 | 1.00 | NFE2L2 (0.53) | NFE2L2XDHALDH1A1KDM4EMAPT | |
| SCHEMBL12651352 | 0.83 | XDH (0.50) | NFE2L2XDHALDH1A1KDM4EMAPT | |
| SCHEMBL22417964 | 0.82 | XDH (0.48) | NFE2L2XDHALDH1A1KDM4EMAPT | |
| SCHEMBL18255202 | 0.82 | XDH (0.48) | NFE2L2XDHALDH1A1KDM4EMAPT | |
| SCHEMBL31335285 | 0.82 | XDH (0.48) | NFE2L2XDHALDH1A1KDM4EMAPT | |
| SCHEMBL18345531 | 0.82 | XDH (0.48) | NFE2L2XDHALDH1A1KDM4EMAPT | |
| SCHEMBL21676224 | 0.82 | XDH (0.48) | NFE2L2XDHALDH1A1KDM4EMAPT | |
| SCHEMBL21676111 | 0.82 | VCP (0.57) | NFE2L2XDHALDH1A1KDM4EMAPT | |
| SCHEMBL14990172 | 0.82 | XDH (0.48) | NFE2L2XDHALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118164996-A | Sesquiterpene lactone scaberol C selenoether derivative, preparation method and application thereof | 沈阳药科大学 | 2024-06-11 | — | — | CN | claimed |
| CN-118164997-A | Sesquiterpene lactone scaberol C thioether derivative, and preparation method and application thereof | 沈阳药科大学 | 2024-06-11 | — | — | CN | claimed |
| CN-118164998-A | Sesquiterpene lactone scaberol C dithio carbamate derivative and preparation method and application thereof | 沈阳药科大学 | 2024-06-11 | — | — | CN | claimed |
| CN-111153910-B | Elephantopus scaber seed lactone derivative and preparation method and application thereof | 沈阳药科大学 | 2021-07-30 | — | — | CN | claimed |
| CN-111153910-A | Elephantopus scaber seed lactone derivative and preparation method and application thereof | 沈阳药科大学 | 2020-05-15 | — | — | CN | claimed |
| CN-118164998-A | Sesquiterpene lactone scaberol C dithio carbamate derivative and preparation method and application thereof | 沈阳药科大学 | 2024-06-11 | — | — | CN | disclosed |
| CN-118164996-A | Sesquiterpene lactone scaberol C selenoether derivative, preparation method and application thereof | 沈阳药科大学 | 2024-06-11 | — | — | CN | disclosed |
| CN-118164997-A | Sesquiterpene lactone scaberol C thioether derivative, and preparation method and application thereof | 沈阳药科大学 | 2024-06-11 | — | — | CN | disclosed |
| CN-108752212-B | 9-decarboxylated rosmarinic acid analogue and synthetic method and application thereof | 北京大学 | 2024-03-12 | — | — | CN | disclosed |
| US-11851433-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2023-12-26 | — | — | US | disclosed |
| US-11851433-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2023-12-26 | — | — | US | disclosed |
| EP-3625234-B1 | HEXAHYDROPYRAZOLO [1,2-A] DIAZEPINONES AND RELATED HETEROCYCLES AS INHIBITORS OF RIP-1 KINASE | DENALI THERAPEUTICS INC (US) | 2023-09-20 | — | — | EP | disclosed |
| WO-2013017678-A1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INTERNATIONAL B.V. (NL) | 2013-02-07 | — | — | WO | disclosed |
| WO-2013017678-A1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INTERNATIONAL B.V. (NL) | 2013-02-07 | — | — | WO | disclosed |
| CN-101910144-A | P-hydroxy-phenyl acrylic acid derivative and application thereof | JINLONG MAO | 2010-12-08 | — | — | CN | disclosed |
| WO-2010123006-A1 | PYRROLIDINE COMPOUND | 武田薬品工業株式会社 (JP) | 2010-10-28 | — | — | WO | disclosed |
| US-20100048513-A1 | Novel inhibitors of chymase | HAWKINS MICHAEL J | 2010-02-25 | — | — | US | disclosed |
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048513-A1 | Novel inhibitors of chymase | CMA1, SERPINB1, TPSAB1 | NFE2L2 3735/4885XDH 621/4885ALDH1A1 1606/4885 |
| US-11851433-B2 | Compounds, compositions and methods | BAX, CASP3, CASP8 | NFE2L2 177/4885XDH 858/4885ALDH1A1 3491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.