Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 2/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27837408 | 0.79 | CHRNB4 (0.35) | KCNH2CCKBRPAX8CHRNB4CHRNA3 | |
| SCHEMBL19158834 | 0.74 | POLB (0.47) | KCNH2PAX8EPHX2 | |
| SCHEMBL2639368 | 0.72 | CCKBR (0.33) | KCNH2CCKBRPAX8CHRNB4CHRNA3 | |
| SCHEMBL31378005 | 0.71 | PAX8 (0.33) | KCNH2PAX8CHRNB4CHRNA3EPHX2 | |
| SCHEMBL28269117 | 0.71 | CCKBR (0.42) | KCNH2CCKBRPAX8 | |
| SCHEMBL27723361 | 0.70 | PAX8 (0.36) | KCNH2CCKBRPAX8 | |
| SCHEMBL3042387 | 0.70 | MTNR1A (0.40) | KCNH2PAX8EPHX2 | |
| SCHEMBL9036022 | 0.69 | EPHX2 (0.40) | KCNH2PAX8EPHX2 | |
| SCHEMBL27739880 | 0.69 | LMNA (0.39) | KCNH2PAX8EPHX2 | |
| SCHEMBL14533235 | 0.69 | CHRNB4 (0.37) | KCNH2CCKBRPAX8CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4454292-A | CHEMICAL INTERMEDIATES OF ANGIOTENSIN CONVERTING ENZYNE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4454291-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4396773-A | 1,1'-[Dithiobis(2-alkyl-1-oxo-3,1-propanediyl)]-bis[2,3-dihydro-1H-indole-2-carboxylic acids and derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-08-02 | — | — | US | disclosed |
| US-4352753-A | 3-[[(2,3-Dihydro-1H-indol-2-yl)carbonyl]thio]propanoic (and acetic) acids as intermediates | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-10-05 | — | — | US | disclosed |
| US-4350633-A | ENZYME INHIBITORS, HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-21 | — | — | US | disclosed |
| US-4303583-A | 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-12-01 | — | — | US | disclosed |