SCHEMBL11050403

SCHEMBL11050403

O=C1C(Cl)=C(Cl)C(=O)N1c1ccccc1OC(F)F

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.44
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
ALDH1A1 P00352 2/20 0.42
MAPT P10636 2/20 0.42
KDM4E B2RXH2 1/20 0.42
GAA P10253 1/20 0.42
TNF P01375 1/20 0.40
MGLL Q99685 1/20 0.38
KCNN4 O15554 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
POLB P06746 1/20 0.37
ALOX15 P16050 1/20 0.37
TSHR P16473 1/20 0.37
CASP1 P29466 1/20 0.37
HSD17B10 Q99714 1/20 0.37
DRD1 P21728 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7609501 0.79 MGLL (0.61) KMT2AMEN1ALDH1A1TNFMGLL
SCHEMBL11638396 0.75 NR1H2 (0.74) NR1H2KMT2AMEN1ALDH1A1MAPT
SCHEMBL10929737 0.71 RAD51 (0.45) KMT2AMEN1ALDH1A1MAPTL3MBTL1
SCHEMBL8460073 0.71 L3MBTL1 (0.60) KMT2AMEN1ALDH1A1MAPTMGLL
SCHEMBL11211240 0.70 MGLL (0.63) KMT2AMEN1ALDH1A1MAPTKDM4E
SCHEMBL395885 0.69 ALDH1A1 (0.64) KMT2AMEN1ALDH1A1MAPTKDM4E
SCHEMBL11052544 0.69 ALDH1A1 (0.44) KMT2AMEN1ALDH1A1MAPTKDM4E
SCHEMBL4654255 0.69 DRD1 (0.48) KMT2AALDH1A1MAPTKDM4EGAA
SCHEMBL8047355 0.68 ALDH1A1 (0.50) KMT2AMEN1ALDH1A1MAPTL3MBTL1
SCHEMBL2682479 0.66 POLB (0.52) KMT2AMEN1ALDH1A1MAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4455315-A N-(Difluoromethoxy substituted phenyl)-dichloromaleimides used in agricultural and horticultural fungicidal methods SHOWA DENKO KABUSHIKI KAISHA (JP) 1984-06-19 US claimed
US-4455315-A N-(Difluoromethoxy substituted phenyl)-dichloromaleimides used in agricultural and horticultural fungicidal methods SHOWA DENKO KABUSHIKI KAISHA (JP) 1984-06-19 US disclosed
US-4455315-A N-(Difluoromethoxy substituted phenyl)-dichloromaleimides used in agricultural and horticultural fungicidal methods SHOWA DENKO KABUSHIKI KAISHA (JP) 1984-06-19 US disclosed