Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | SLC25A20 | O43772 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762175 | 0.97 | CA2 (0.44) | RECQLCA2SLC25A20TP53CYP2D6 | |
| SCHEMBL478459 | 0.96 | GPR84 (0.42) | RECQLCA2SLC25A20TP53CYP2D6 | |
| SCHEMBL8376547 | 0.96 | GPR84 (0.42) | RECQLCA2SLC25A20TP53CYP2D6 | |
| SCHEMBL28190358 | 0.93 | RECQL (0.46) | RECQLCA2SLC25A20TP53CYP2D6 | |
| SCHEMBL8402079 | 0.90 | CA1 (0.38) | RECQLCA2SLC25A20TP53CYP2D6 | |
| SCHEMBL5965211 | 0.89 | RECQL (0.43) | RECQLCA2SLC25A20TP53CYP2D6 | |
| SCHEMBL16266427 | 0.87 | CA1 (0.38) | RECQLCA2SLC25A20TP53CYP2D6 | |
| SCHEMBL10798914 | 0.86 | RECQL (0.48) | RECQLCA2SLC25A20TP53CYP2D6 | |
| SCHEMBL478457 | 0.86 | GPR84 (0.41) | CA2SLC25A20TP53CYP2D6TSHR | |
| SCHEMBL9131227 | 0.86 | GPR84 (0.41) | CA2SLC25A20TP53CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4465756-A | Electrostatographic enscapsulated toner material improved in chargeability | FUJI PHOTO FILM CO., LTD. (JP) | 1984-08-14 | — | — | US | disclosed |