SCHEMBL11057683

SCHEMBL11057683

CCN(OCc1ccccc1)c1ncn(-c2c(C)cccc2Br)c(=O)n1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 4/20 0.34
CHRNA7 P36544 1/20 0.33
STAT3 P40763 1/20 0.31
HTT P42858 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PTGER1 P34995 1/20 0.31
P2RX7 Q99572 2/20 0.31
MAPT P10636 1/20 0.31
MAPK1 P28482 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CYP1A2 P05177 1/20 0.31
MAT2A P31153 1/20 0.31
PKM P14618 1/20 0.31
MAOA P21397 1/20 0.31
MAOB P27338 1/20 0.31
HCAR1 Q9BXC0 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11052478 0.90 TDP2 (0.33) MAPK14CHRNA7P2RX7MAPK1CYP1A2
SCHEMBL11056305 0.90 MEN1 (0.38) MAPK14CHRNA7STAT3HTTSMN1; SMN2
SCHEMBL11059306 0.88 CHRNA7 (0.45) MAPK14CHRNA7P2RX7
SCHEMBL11055462 0.85 HCAR2 (0.35) MAPK14STAT3HTTSMN1; SMN2CYP1A2
SCHEMBL11059289 0.80 HCAR1 (0.36) CHRNA7SMN1; SMN2HCAR1
SCHEMBL11053236 0.80 HCAR1 (0.38) CHRNA7MAPK1CYP1A2MAT2AHCAR1
SCHEMBL11059411 0.80 KMT2A (0.36) CHRNA7MAPK1CYP1A2MAT2AMAOA
SCHEMBL11055971 0.79 HCAR1 (0.36) CHRNA7CYP1A2MAT2AHCAR1
SCHEMBL11055027 0.78 CHRNA7 (0.44) MAPK14CHRNA7P2RX7L3MBTL1
SCHEMBL11060185 0.74 ALDH1A1 (0.33) MAPK14STAT3HTTSMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed