Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11060030 | 0.92 | LMNA (0.36) | ALDH1A1ALOX15TSHRHSD17B10KDM4E | |
| SCHEMBL11066911 | 0.87 | KDM1A (0.41) | ALDH1A1ALOX15TSHRHSD17B10KDM4E | |
| SCHEMBL11072105 | 0.81 | SRD5A1 (0.35) | L3MBTL1 | |
| SCHEMBL11062697 | 0.80 | LMNA (0.40) | ALDH1A1ALOX15TSHRHSD17B10KDM4E | |
| SCHEMBL11065609 | 0.80 | HRH1 (0.39) | ALDH1A1ALOX15TSHRHSD17B10KDM4E | |
| SCHEMBL11068485 | 0.77 | L3MBTL1 (0.42) | ALDH1A1KDM4EKDM1ALMNAL3MBTL1 | |
| SCHEMBL11066786 | 0.77 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDKDM1ALMNA | |
| SCHEMBL11071003 | 0.76 | MAPK14 (0.42) | ALDH1A1TSHRGABRA1GABRG2GABRB3 | |
| SCHEMBL11186665 | 0.75 | KDM1A (0.36) | ALDH1A1TSHRHSD17B10KDM4EHPGD | |
| SCHEMBL11063136 | 0.75 | PTGDR2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4440779-A | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0068460-A1 | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | disclosed |