Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 3/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11065747 | 0.88 | ADRB1 (0.54) | ADRB1HTR1AADRB2OPRK1SCN1A | |
| Hydrochloric Acid SCHEMBL11068651 | 0.82 | HTR1A (0.39) | ADRB1HTR1AADRB2OPRK1SCN1A | |
| SCHEMBL11073906 | 0.82 | SCN1A (0.70) | ADRB1HTR1AADRB2OPRK1SCN1A | |
| Iodide SCHEMBL11063509 | 0.79 | ADRB1 (0.54) | ADRB1HTR1AADRB2OPRK1SCN1A | |
| Iodide SCHEMBL11073338 | 0.74 | ADRB2 (0.39) | ADRB1HTR1AADRB2OPRK1SCN1A | |
| Hydrochloric Acid SCHEMBL11073701 | 0.73 | DRD2 (0.49) | DRD3 | |
| SCHEMBL11065159 | 0.72 | SCN1A (0.49) | HTR1ASCN1ASCN5ASCN9ADRD1 | |
| SCHEMBL10656269 | 0.72 | ADRB1 (0.69) | ADRB1HTR1AADRB2OPRK1SCN1A | |
| Iodide SCHEMBL11071817 | 0.71 | SLC18A3 (0.46) | ADRB1HTR1AADRB2OPRK1SCN1A | |
| Iodide SCHEMBL11068796 | 0.71 | SLC18A3 (0.45) | ADRB1HTR1AADRB2OPRK1SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482560-A | Carbostyril derivatives, and antihistaminic agents containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-13 | — | — | US | disclosed |