Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 11/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11060976 | 0.88 | GRM2 (0.43) | GRM2HTR2BIRAK4PKMMAPK1 | |
| SCHEMBL11067481 | 0.86 | GRM2 (0.38) | GRM2HTR2BIRAK4PKMMAPK1 | |
| SCHEMBL11064738 | 0.83 | CA2 (0.41) | GRM2HTR2BIRAK4PKMMAPK1 | |
| SCHEMBL9225959 | 0.82 | PDK1 (0.46) | GRM2HTR2BMAPK1L3MBTL1 | |
| SCHEMBL9225971 | 0.82 | PDK1 (0.46) | GRM2HTR2BMAPK1L3MBTL1 | |
| SCHEMBL11071694 | 0.82 | PARP1 (0.44) | GRM2HTR2BPKMMAPK1L3MBTL1 | |
| SCHEMBL11068306 | 0.81 | ADRB2 (0.44) | GRM2HTR2B | |
| SCHEMBL11069100 | 0.78 | HTR2B (0.42) | GRM2HTR2B | |
| SCHEMBL11220571 | 0.77 | HTR1A (0.45) | MAPK1 | |
| SCHEMBL11875374 | 0.76 | HTR2B (0.47) | GRM2HTR2BPKMMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064294-A1 | 1,5-Substituted isoquinoline derivatives | G.D. Searle & Co. (US) | 1982-11-10 | — | — | EP | claimed |
| US-4473501-A | HYPOTENSIVES | G. D. SEARLE & CO. (US) | 1984-09-25 | — | — | US | disclosed |
| EP-0064294-A1 | 1,5-Substituted isoquinoline derivatives | G.D. Searle & Co. (US) | 1982-11-10 | — | — | EP | disclosed |