Sugi Predict

Sugi Predict / Compounds / SCHEMBL1107146

SCHEMBL1107146

SCHEMBL1107146

CCOC(=O)Cc1ccc(C)cc1

nearest known ligand 0.68

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ CYP4Z1 Q86W10 1/20 0.57
▸ KMT2A Q03164 2/20 0.56
▸ MEN1 O00255 1/20 0.56
▸ MAPT P10636 2/20 0.54
▸ LMNA P02545 3/20 0.51
▸ SMN1; SMN2 Q16637 1/20 0.51
▸ CYP1A2 P05177 1/20 0.50
▸ CYP2C9 P11712 1/20 0.50
▸ CYP4F2 P78329 1/20 0.50
▸ CYP4A11 Q02928 1/20 0.50
▸ HPGD P15428 2/20 0.49
▸ ALDH1A1 P00352 2/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ TSHR P16473 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ CTBP2 P56545 1/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL8786038 0.94 CYP4Z1 (0.56) CYP4Z1KMT2AMEN1MAPTLMNA
SCHEMBL68851 0.94 CYP4Z1 (0.62) CYP4Z1KMT2AMEN1MAPTLMNA
SCHEMBL10467736 0.89 CYP4F2 (0.50) CYP4Z1KMT2AMEN1MAPTLMNA
SCHEMBL18198264 0.88 KMT2A (0.56) KMT2AMEN1LMNACYP1A2CYP2C9
SCHEMBL68930 0.88 CYP4Z1 (0.57) CYP4Z1MAPTLMNASMN1; SMN2CYP4F2
SCHEMBL10299459 0.88 CYP4Z1 (0.57) CYP4Z1KMT2AMEN1MAPTLMNA
SCHEMBL6057577 0.88 CYP4F2 (0.59) CYP4Z1KMT2AMEN1MAPTLMNA
SCHEMBL2400474 0.86 KMT2A (0.51) CYP4Z1KMT2AMEN1CYP1A2CYP2C9
SCHEMBL18932531 0.86 CYP4Z1 (0.55) CYP4Z1KMT2AMEN1MAPTLMNA
SCHEMBL13932524 0.86 ALDH1A1 (0.66) KMT2AMEN1MAPTLMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 254 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108997188-B Synthetic method of erexib 苏州富士莱医药股份有限公司 2021-08-31 — — CN claimed
CN-111793193-A Solvent-free type 180-DEG C-resistant ultralow-viscosity epoxy resin matrix and preparation method thereof 黑龙江省科学院石油化学研究院 2020-10-20 — — CN claimed
CN-105523874-A Preparation method of 2,2-dihalo-1,3-dicarbonyl derivatives ZHANGJIAGANG INST IND TECHNOLOGIES SOOCHOW UNIV 2016-04-27 — — CN claimed
CN-105503635-A Preparation method for 2-amidoformyl-1,3-dicarbonyl derivative UNIV SOOCHOW 2016-04-20 — — CN claimed
CN-105461496-A Preparation method for 2-halogenated-1,3-dicarbonyl derivative CHINASUN SPECIALTY PRODUCTS CO LTD 2016-04-06 — — CN claimed
CN-116135892-B Method for preparing bimodal polyethylene resin for pipe material and bimodal polyethylene resin thereof 中国石油化工股份有限公司 2024-10-15 — — CN disclosed
US-20240294495-A1 COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF MONTE ROSA THERAPEUTICS AG (CH) 2024-09-05 — — US disclosed
US-20240228491-A1 METHIONINE ADENOSYLTRANSFERASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SCINNOHUB PHARMACEUTICAL CO., LTD. (CN) 2024-07-11 — — US disclosed
US-20230381196-A1 COMPOSITIONS COMPRISING BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS FOR TREATING ADENOID CYSTIC CARCINOMA AYALA PHARMACEUTICALS INC. (US) 2023-11-30 — — US disclosed
CN-117003915-A Solid catalyst component, preparation method thereof, olefin polymerization catalyst and application 中国石油化工股份有限公司 2023-11-07 — — CN disclosed
US-20230295490-A1 LIGHT-EMITTING NANOPARTICLES AND LIGHT-EMITTING LABELING MATERIAL FOR PATHOLOGICAL DIAGNOSIS Konica Minolta, Inc. (JP) 2023-09-21 — — US disclosed
CN-115322204-B Preparation method and application of radix glycyrrhizae glabra A and derivatives thereof 广西中医药大学 2023-09-19 — — CN disclosed
US-4309544-A CONDENSATION OF 2-METHYLENE-QUINUCLIDIN-3-ONE WITH A KETONE OR AN THE PURDUE FREDERICK COMPANY (US) 1982-01-05 — — US disclosed
US-4297234-A OPTICAL BRIGHTENERS CIBA-GEIGY CORPORATION (US) 1981-10-27 — — US disclosed
US-4283548-A Diisatoic acid or triisatoic acid derivatives LIM-HOLDING S.A (LU) 1981-08-11 — — US disclosed
US-4226996-A 4-SUBSTITUTED-6-OXA-1-AZATRICYCLO/4.2.2.0.2.7/DODECAN-5-ONE SALT THE PURDUE FREDERICK COMPANY (US) 1980-10-07 — — US disclosed
US-4183938-A 1,8-Ethano-5-oxo-octa- and -decahydroquinolines and mydriatic compositions thereof THE PURDUE FREDERICK COMPANY (US) 1980-01-15 — — US disclosed
US-4083985-A 6-Oxa-1-aza tricyclo dodecan-5-ones as psychomotor stimulators THE PURDUE FREDERICK COMPANY (US) 1978-04-11 — — US disclosed
US-3940486-A Imidazole derivatives in the treatment of pain CIBA-GEIGY CORPORATION (US) 1976-02-24 — — US disclosed
US-3932465-A ANTIBIOTIC CIBA-GEIGY CORPORATION (US) 1976-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230381196-A1 COMPOSITIONS COMPRISING BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS FOR TREATING ADENOID CYSTIC CARCINOMA AKR1C3, AKR1D1, CYP2C19 CYP4Z1 203/4885KMT2A 2591/4885MEN1 2816/4885
US-20240294495-A1 COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF CRBN, GSPT1, GSPT2 CYP4Z1 3379/4885KMT2A 3745/4885MEN1 196/4885
US-20240228491-A1 METHIONINE ADENOSYLTRANSFERASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF MAT1A, AMD1, MAT2B CYP4Z1 738/4885KMT2A 436/4885MEN1 525/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.