Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 7/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074440 | 0.86 | AKT1 (0.46) | LMNAUTS2RSLC6A4HTR7KCNH2 | |
| SCHEMBL11075657 | 0.82 | LMNA (0.42) | LMNAUTS2RSLC6A4DRD2HTR2A | |
| SCHEMBL29165243 | 0.76 | SIGMAR1 (0.39) | LMNASIGMAR1DRD2HTR2AALDH1A1 | |
| SCHEMBL19995132 | 0.76 | SIGMAR1 (0.44) | LMNASIGMAR1DRD2HTR2ACYP2D6 | |
| SCHEMBL31429831 | 0.72 | SIGMAR1 (0.39) | LMNASIGMAR1DRD2HTR2ACYP2D6 | |
| SCHEMBL11274144 | 0.71 | SIGMAR1 (0.42) | SLC6A4SIGMAR1DRD2HTR2ASLC6A2 | |
| SCHEMBL11074383 | 0.71 | SMN1; SMN2 (0.40) | LMNASLC6A4SIGMAR1DRD2HTR2A | |
| SCHEMBL9113086 | 0.70 | SIGMAR1 (0.46) | SIGMAR1DRD2HTR2AHTR2CADRA1A | |
| SCHEMBL28798029 | 0.69 | SIGMAR1 (0.39) | SIGMAR1DRD2HTR2AMAPTALDH1A1 | |
| SCHEMBL11220183 | 0.67 | HSD11B1 (0.46) | SIGMAR1DRD2HTR2AALDH1A1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452801-A | ANTIINFLAMMATORY AGENTS, ANTICOAGULATNS, ANTIALLERGENS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4360532-A | ANTIINFLAMMATORY AGENTS, ANTICOAGULANTS, ANTIALLERGENS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-11-23 | — | — | US | disclosed |
| US-4321270-A | ANTIINFLAMMATORY AGENT, ANTIAGGLOMERANTS, AND HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-03-23 | — | — | US | disclosed |