Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ME2 | P23368 | 2/20 | 0.57 |
| ▸ | ME1 | P48163 | 2/20 | 0.57 |
| ▸ | ME3 | Q16798 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080396 | 0.86 | POLB (0.50) | ME2ME1ME3KDM4EPOLB | |
| SCHEMBL11082813 | 0.84 | GFER (0.57) | ME2ME1ME3KDM4EPOLB | |
| SCHEMBL11090165 | 0.80 | GNAI3 (0.49) | ME2ME1ME3KDM4EPOLB | |
| SCHEMBL14768692 | 0.75 | SLC6A7 (0.51) | KDM4EPOLBALDH1A1MAPTLMNA | |
| SCHEMBL22481434 | 0.74 | SLC6A7 (0.53) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL8097277 | 0.74 | HPGD (0.63) | ALDH1A1NAAAHPGDMEN1KMT2A | |
| SCHEMBL11076159 | 0.74 | ADRB2 (0.57) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL11083771 | 0.74 | HRH3 (0.62) | LMNA | |
| SCHEMBL11079083 | 0.73 | KDM4E (0.57) | KDM4EPOLBGRM5ALDH1A1MAPT | |
| SCHEMBL11077598 | 0.73 | ATM (0.51) | ME2ME1ME3KDM4EGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4439606-A | ANTICHOLESTEROL, ANTILIPEMIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-03-27 | — | — | US | claimed |
| US-4439606-A | ANTICHOLESTEROL, ANTILIPEMIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-03-27 | — | — | US | disclosed |
| EP-0094498-A2 | Antiatherosclerotic 1-piperazine derivatives | AMERICAN CYANAMID COMPANY (US) | 1983-11-23 | — | — | EP | disclosed |