Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ME2 | P23368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11083771 | 0.86 | HRH3 (0.62) | HRH3LMNAHTR1ADRD2DRD4 | |
| SCHEMBL11077602 | 0.86 | ME2 (0.57) | POLBSLC6A7KDM4ELMNAMAPT | |
| SCHEMBL11082813 | 0.80 | GFER (0.57) | POLBSLC6A7KDM4EHPGDHSD17B10 | |
| SCHEMBL11090165 | 0.79 | GNAI3 (0.49) | POLBSLC6A7HRH3KDM4ELMNA | |
| SCHEMBL14768692 | 0.76 | SLC6A7 (0.51) | POLBSLC6A7HRH3KDM4ELMNA | |
| SCHEMBL24449115 | 0.75 | HTR1A (0.55) | POLBSLC6A7HRH3KDM4EHPGD | |
| SCHEMBL22481434 | 0.75 | SLC6A7 (0.53) | POLBSLC6A7HRH3KDM4EHPGD | |
| SCHEMBL11079083 | 0.74 | KDM4E (0.57) | POLBSLC6A7KDM4ELMNAMAPT | |
| SCHEMBL14411664 | 0.74 | SLC6A7 (0.54) | SLC6A7HRH3KDM4EHPGDHSD17B10 | |
| SCHEMBL10968173 | 0.73 | TRPV1 (0.67) | KDM4ELMNAMAPTMAPK1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4439606-A | ANTICHOLESTEROL, ANTILIPEMIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-03-27 | — | — | US | claimed |
| US-4439606-A | ANTICHOLESTEROL, ANTILIPEMIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-03-27 | — | — | US | disclosed |
| EP-0094498-A2 | Antiatherosclerotic 1-piperazine derivatives | AMERICAN CYANAMID COMPANY (US) | 1983-11-23 | — | — | EP | disclosed |