Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Propiram. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.48 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propiram SCHEMBL592478 | 1.00 | MEN1 (0.48) | MEN1KMT2AHTR1AACHEOPRM1 | |
| Propiram SCHEMBL29725982 | 1.00 | MEN1 (0.48) | MEN1KMT2AHTR1AACHEOPRM1 | |
| Propiram SCHEMBL38655379 | 0.94 | MEN1 (0.52) | MEN1KMT2AHTR1AACHEOPRM1 | |
| Propiram SCHEMBL26193 | 0.94 | MEN1 (0.52) | MEN1KMT2AHTR1AACHEOPRM1 | |
| Propiram SCHEMBL3093165 | 0.92 | MEN1 (0.52) | MEN1KMT2AHTR1AACHEOPRM1 | |
| SCHEMBL26930970 | 0.80 | OPRM1 (0.43) | MEN1KMT2AHTR1AOPRM1SIGMAR1 | |
| Phenampromide SCHEMBL907886 | 0.78 | OPRM1 (0.47) | MEN1KMT2AOPRM1SMN1; SMN2 | |
| Phenampromide SCHEMBL907884 | 0.78 | OPRM1 (0.47) | MEN1KMT2AOPRM1SMN1; SMN2 | |
| Phenampromide SCHEMBL11661873 | 0.77 | ALDH1A1 (0.49) | MEN1KMT2AOPRM1SMN1; SMN2 | |
| Phenampromide SCHEMBL11661877 | 0.77 | ALDH1A1 (0.49) | MEN1KMT2AOPRM1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4479956-A | Analgesic compositions comprising propiram and methods of using same | ANALGEIC ASSOCIATES (US) | 1984-10-30 | — | — | US | disclosed |