Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 7/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11093528 | 0.93 | CXCR6 (0.47) | TSHRSIGMAR1DRD4DRD3CXCR6 | |
| SCHEMBL11094396 | 0.92 | SIGMAR1 (0.46) | TSHRSIGMAR1DRD4DRD3CXCR6 | |
| SCHEMBL11270864 | 0.92 | CXCR4 (0.46) | TSHRSIGMAR1DRD4DRD3 | |
| SCHEMBL11097324 | 0.91 | DRD4 (0.48) | TSHRDRD4DRD3DRD2 | |
| SCHEMBL11098468 | 0.89 | TSHR (0.44) | TSHRSIGMAR1DRD4DRD3DRD2 | |
| SCHEMBL11094870 | 0.86 | DRD2 (0.51) | TSHRDRD2 | |
| SCHEMBL11095214 | 0.86 | UBE2M (0.44) | TSHRSIGMAR1DRD4DRD3CXCR6 | |
| SCHEMBL11100998 | 0.85 | ALDH1A1 (0.50) | SIGMAR1CXCR6MEN1KMT2A | |
| SCHEMBL11100155 | 0.83 | OPRM1 (0.45) | TSHRMEN1KMT2A | |
| SCHEMBL11096161 | 0.83 | DRD4 (0.51) | TSHRDRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031219-A1 | Aniline derivatives | BEECHAM GROUP PLC (GB) | 1981-07-01 | — | — | EP | claimed |
| EP-0031219-B1 | ANILINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1984-03-07 | — | — | EP | disclosed |
| US-4350691-A | ANTIEMETICS | BEECHAM GROUP LIMITED (GB) | 1982-09-21 | — | — | US | disclosed |
| EP-0031219-A1 | Aniline derivatives | BEECHAM GROUP PLC (GB) | 1981-07-01 | — | — | EP | disclosed |