Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11101318 | 0.87 | SIGMAR1 (0.49) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL8119451 | 0.85 | CASP6 (0.49) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9253569 | 0.85 | DRD2 (0.66) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL11095799 | 0.85 | ALDH1A1 (0.55) | ALDH1A1SIGMAR1DRD2HTR2AHTR2C | |
| SCHEMBL7438856 | 0.85 | BRD4 (0.46) | ALDH1A1SMN1; SMN2SIGMAR1DRD2HTR2A | |
| SCHEMBL11095969 | 0.83 | POLB (0.50) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9252290 | 0.83 | SIGMAR1 (0.46) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL9255015 | 0.82 | MBTD1 (0.46) | ALDH1A1SIGMAR1DRD2HTR2AHTR2C | |
| SCHEMBL9253376 | 0.81 | HDAC1 (0.45) | ALDH1A1SIGMAR1DRD2HTR2AHTR2C | |
| SCHEMBL2317845 | 0.80 | KMT2A (0.67) | ALDH1A1KDM1AMAOAMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037713-B1 | NOVEL 1,3-DIHYDRO-1-((1-PIPERIDINYL)ALKYL)-2H-BENZIMIDAZOL-2-ONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-02-08 | — | — | EP | disclosed |
| EP-0037713-A1 | Novel 1,3-dihydro-1-((1-piperidinyl)alkyl)-2H-benzimidazol-2-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-10-14 | — | — | EP | disclosed |
| US-4254127-A | ANTIEMETIC, NEUROLIPTIC AND ANTICONGESTIVE AGENT | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-03-03 | — | — | US | disclosed |