Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | S100A4 | P26447 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11110418 | 0.78 | NOTUM (0.31) | NOTUMHSD17B10MEN1KMT2AKDM4E | |
| SCHEMBL11117091 | 0.71 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL19216725 | 0.64 | TYMS (0.40) | MEN1KMT2AALDH1A1TYMSUSP2 | |
| SCHEMBL30067557 | 0.63 | TYMS (0.57) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| Acetic Acid SCHEMBL28550221 | 0.63 | SRD5A1 (0.58) | NOTUMHSD17B10HSD17B1CASP1CASP7 | |
| SCHEMBL11109712 | 0.62 | CASP1 (0.36) | HSD17B10MEN1KMT2ATYMSHSD17B1 | |
| SCHEMBL21948632 | 0.60 | TYMS (0.53) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6625286 | 0.60 | CNR1 (0.34) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL8253223 | 0.59 | NPC1 (0.61) | HSD17B10HSD17B1PBRM1CASP1CASP7 | |
| SCHEMBL8283186 | 0.57 | CASP1 (0.50) | HSD17B10HSD17B1PBRM1CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0033767-B1 | INDOLOBENZOXAZINES, PROCESSES FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | MERCK & CO. INC. (US) | 1984-06-27 | — | — | EP | disclosed |
| EP-0033767-A1 | Indolobenzoxazines, processes for preparing and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1981-08-19 | — | — | EP | disclosed |
| US-4238486-A | TREATING HYPERTENSION AND PARKINSON*S DISEASE | MERCK & CO., INC. (US) | 1980-12-09 | — | — | US | disclosed |