Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114262 | 0.81 | CA2 (0.40) | HTTMAPTGAAALDH1A1L3MBTL1 | |
| SCHEMBL4215302 | 0.69 | HTT (0.42) | HTTMAPTGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL8433529 | 0.67 | L3MBTL1 (0.39) | HTTMAPTGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL7920060 | 0.66 | PDE7A (0.60) | HTTMAPTGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL4707544 | 0.65 | PDE7A (0.48) | HTTMAPTGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL10889559 | 0.64 | ALDH1A1 (0.69) | HCAR3GAASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL27830765 | 0.64 | TSHR (0.50) | HTTMAPTGAAALDH1A1CYP1A2 | |
| SCHEMBL10951675 | 0.63 | DTYMK (0.39) | HTTMAPTGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL4603436 | 0.63 | MAPT (0.57) | HTTMAPTGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL1901606 | 0.63 | CLCN2 (0.53) | HCAR3SMN1; SMN2ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279174-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009143246-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-11-26 | — | — | WO | disclosed |