Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6274633 | 0.76 | RAB9A (0.76) | RAB9AMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL12067057 | 0.66 | MAOB (0.56) | KMT2AMEN1ALDH1A1HPGDCYP19A1 | |
| SCHEMBL855370 | 0.65 | RAB9A (1.00) | RAB9AMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL28015323 | 0.63 | TLR8 (0.62) | RAB9AMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL4318498 | 0.62 | — | — | |
| SCHEMBL2423284 | 0.60 | ERN1 (0.57) | MAPTSMN1; SMN2TSHRALDH1A1HPGD | |
| SCHEMBL7983584 | 0.59 | PDE4D (0.47) | SMN1; SMN2GAAKMT2AMEN1PDE4D | |
| SCHEMBL6284499 | 0.59 | RAB9A (0.74) | RAB9AMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL15741689 | 0.59 | IMPDH2 (0.54) | RAB9AMAPTNPC1GAATSHR | |
| SCHEMBL31369142 | 0.59 | CA1 (0.56) | MAPTKMT2ATSHRMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953856-B2 | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) | USV, LIMITED (IN) | 2005-10-11 | — | — | US | claimed |
| US-20040158070-A1 | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) | USV LIMITED, BSD MARG. (IN) | 2004-08-12 | — | — | US | claimed |
| CN-110540520-B | Method for purifying donepezil | 迪嘉药业集团有限公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-110540520-A | Method for purifying donepezil | WEIHAI DISU PHARMACEUTICAL CO LTD | 2019-12-06 | — | — | CN | disclosed |
| EP-2278970-B1 | PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE | CIPLA LTD (IN) | 2015-04-22 | — | — | EP | disclosed |
| EP-2278970-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE | Cipla Limited (IN) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009118516-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE | CIPLA LIMITED (GB) | 2009-10-01 | — | — | WO | disclosed |
| WO-2008010235-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF DONEPEZIL | TORRENT PHARMACEUTICALS LIMITED (IN) | 2008-01-24 | — | — | WO | disclosed |
| US-20070129549-A1 | Stable lamotrigine pharmaceutical compositions and processes for their preparation | RANBAXY LABORATORIES LIMITED (IN) | 2007-06-07 | — | — | US | disclosed |
| EP-1531151-B1 | A process for the preparation of 1-benzyl-4-¬(5,6-dimethoxy-1-indanon)-2-yl| methyl piperidine hydrochloride (donepezil hcl) | USV LTD (IN) | 2007-03-07 | — | — | EP | disclosed |
| EP-1608371-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND DERIVATIVES THEREOF | RANBAXY LABORATORIES, LTD. (IN) | 2005-12-28 | — | — | EP | disclosed |
| US-6953856-B2 | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) | USV, LIMITED (IN) | 2005-10-11 | — | — | US | disclosed |
| EP-1531151-A1 | A process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine hydrochloride (donepezil hcl) | USV Limited (IN) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004082685-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND DERIVATIVES THEREOF | RANBAXY LABORATORIES LIMITED (IN) | 2004-09-30 | — | — | WO | disclosed |
| US-20040158070-A1 | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) | USV LIMITED, BSD MARG. (IN) | 2004-08-12 | — | — | US | disclosed |
| US-6252081-B1 | REDUCING OF THE COORRESPONDING QUATERNARY AMMONIUM SALT | EISAI CO., LTD. (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0711756-B1 | Process for the production of benzyl-piperidylmethyl-indanone | BAYER AG (DE) | 1998-07-22 | — | — | EP | disclosed |
| US-5606064-A | Process for the preparation of benzyl-piperidylmethyl-indanones | BAYER AKTIENGESELLSCHAFT (DE) | 1997-02-25 | — | — | US | disclosed |
| EP-0711756-A1 | Process for the production of benzyl-piperidylmethyl-indanone | BAYER AG (DE) | 1996-05-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129549-A1 | Stable lamotrigine pharmaceutical compositions and processes for their preparation | KCNJ1, KCNJ8, KCNJ2 | RAB9A 3428/4885MAPT 86/4885SMN1; SMN2 1051/4885 |
| US-20040158070-A1 | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) | HCN1, HNMT, H1-5 | RAB9A 3943/4885MAPT 697/4885SMN1; SMN2 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.