Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 3/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11159629 | 0.87 | APP (0.55) | SMN1; SMN2ALDH1A1MAPTAPPHPGD | |
| SCHEMBL10512932 | 0.86 | ALDH1A1 (0.48) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL10513531 | 0.84 | MGLL (0.43) | KMT2ASMN1; SMN2MEN1ALDH1A1KDM4E | |
| SCHEMBL10514900 | 0.83 | MGLL (0.41) | SMN1; SMN2ALDH1A1MGLLRAB9A | |
| SCHEMBL11159483 | 0.83 | OPRM1 (0.44) | KMT2ASMN1; SMN2ALDH1A1HPGDOPRD1 | |
| SCHEMBL11153193 | 0.81 | L3MBTL1 (0.47) | KMT2ASMN1; SMN2ALDH1A1LMNAMGLL | |
| SCHEMBL10515575 | 0.81 | ADRA1D (0.39) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL11225821 | 0.80 | MGLL (0.41) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL11160332 | 0.79 | ADRA1D (0.47) | MGLL | |
| SCHEMBL11150886 | 0.78 | CYP2D6 (0.47) | SMN1; SMN2ALDH1A1KDM4EMGLLOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023706-B1 | 4-PHENOXY PIPERIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |
| US-4333942-A | Anti-depressant and analgesic 4-phenoxypiperidines | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-08 | — | — | US | disclosed |
| EP-0023706-A1 | 4-Phenoxy piperidines, process for their preparation, their use and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |