Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 8/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11195295 | 0.90 | ACE (0.38) | ACEPOLBALDH1A1HPGDFFAR2 | |
| SCHEMBL11267053 | 0.82 | FFAR2 (0.41) | ACEPOLBFFAR2GAARAB9A | |
| SCHEMBL10969787 | 0.82 | ACE (0.57) | ACEPOLBALDH1A1HPGDFFAR2 | |
| SCHEMBL11191943 | 0.81 | ALDH1A1 (0.43) | ACEPOLBALDH1A1HPGDFFAR2 | |
| SCHEMBL11192578 | 0.81 | LMNA (0.53) | ACEPOLBALDH1A1HPGDFFAR2 | |
| SCHEMBL11187368 | 0.81 | TERT (0.41) | FFAR2L3MBTL1TERTPTGS2 | |
| SCHEMBL11257867 | 0.80 | HSD17B10 (0.45) | ACEPOLBALDH1A1HPGDFFAR2 | |
| SCHEMBL11191864 | 0.77 | ACE (0.53) | ACEPOLBALDH1A1HPGDFFAR2 | |
| SCHEMBL10944250 | 0.76 | ACE (0.53) | ACEPOLBALDH1A1HPGDFFAR2 | |
| SCHEMBL10999352 | 0.76 | ACE (0.52) | ACEPOLBFFAR2TERTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | claimed |
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |