Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11194045 | 0.77 | ACE (0.51) | ACEALDH1A1 | |
| SCHEMBL11192048 | 0.74 | ACE (0.43) | ACEHSD17B10 | |
| SCHEMBL11263001 | 0.74 | POLB (0.40) | ACEHSD17B10KDM4EALDH1A1 | |
| SCHEMBL11190617 | 0.74 | FFAR2 (0.44) | ACEHSD17B10KDM4EALDH1A1 | |
| SCHEMBL11184581 | 0.74 | POLB (0.40) | HSD17B10ALDH1A1 | |
| SCHEMBL11190514 | 0.73 | ACE (0.55) | ACE | |
| SCHEMBL11197073 | 0.73 | ACE (0.55) | ACE | |
| SCHEMBL11189268 | 0.73 | ALDH1A1 (0.44) | KDM4EALDH1A1 | |
| SCHEMBL11202283 | 0.72 | POLB (0.38) | HSD17B10KDM4EALDH1A1 | |
| SCHEMBL11194364 | 0.71 | ACE (0.52) | ACEHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |