SCHEMBL11212409

SCHEMBL11212409

NNS(=O)(=O)c1cccc(Oc2cccc(S(=O)(=O)NN)c2)c1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PGR P06401 10/20 0.53
MEN1 O00255 1/20 0.44
CASP6 P55212 1/20 0.44
GFER P55789 1/20 0.44
KMT2A Q03164 1/20 0.44
KAT6A Q92794 1/20 0.44
PTGES2 Q9H7Z7 1/20 0.44
FFAR4 Q5NUL3 1/20 0.44
KEAP1 Q14145 1/20 0.44
NFE2L2 Q16236 1/20 0.44
TNNI3K Q59H18 1/20 0.44
ALDH1A1 P00352 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
NR3C1 P04150 1/20 0.42
AR P10275 1/20 0.42
ESR2 Q92731 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL421587 0.85 KEAP1 (0.60) PGRKAT6APTGES2FFAR4KEAP1
SCHEMBL148204 0.83 CA2 (0.54) MEN1CASP6GFERKMT2AALDH1A1
SCHEMBL18261208 0.81 SMN1; SMN2 (0.49) PGRMEN1CASP6GFERKMT2A
SCHEMBL11101389 0.78 PTGES2 (0.50) MEN1CASP6GFERKMT2APTGES2
SCHEMBL138127 0.78 KMT2A (0.58) MEN1CASP6GFERKMT2AALDH1A1
SCHEMBL22492260 0.77 ACHE (0.47) KAT6AFFAR4KEAP1NFE2L2ALDH1A1
SCHEMBL6681003 0.77 SOS1 (0.63) PGRFFAR4ALDH1A1SMN1; SMN2
SCHEMBL9234846 0.77 PGR (0.73) PGRMEN1KMT2AKEAP1ALDH1A1
SCHEMBL620147 0.77 PGR (0.60) PGRKAT6ATNNI3KSMN1; SMN2NR3C1
SCHEMBL11406378 0.76 LMNA (0.63) KMT2AKAT6AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3966651-A Process for the production of fine-cell polyolefin foams BAYER AKTIENGESELLSCHAFT (DT) 1976-06-29 US claimed
EP-0030333-B1 ALKYLDIPHENYL-ETHER SULFONIC ACID HYDRAZIDES, THEIR PRODUCTION AND USE AS BLOWING AGENTS BAYER AG (DE) 1983-03-09 EP disclosed
US-4329499-A Alkyldiphenyl ether-sulphonic acid hydrazides, their preparation and their use as blowing agents BAYER AKTIENGESELLSCHAFT (DE) 1982-05-11 US disclosed
EP-0030333-A1 Alkyldiphenyl-ether sulfonic acid hydrazides, their production and use as blowing agents BAYER AG (DE) 1981-06-17 EP disclosed