Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.53 |
| ▸ | DRD4 | P21917 | 9/20 | 0.53 |
| ▸ | HTR2A | P28223 | 5/20 | 0.53 |
| ▸ | HRH1 | P35367 | 5/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.53 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.45 |
| ▸ | DRD3 | P35462 | 5/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11241625 | 0.84 | SLC18A3 (0.47) | DRD2DRD4HTR2AHRH1HTR1A | |
| SCHEMBL11236713 | 0.78 | DRD2 (0.49) | DRD2DRD4HTR2AHRH1HTR1A | |
| SCHEMBL11236973 | 0.74 | SLC18A3 (0.51) | DRD2DRD4HTR2AHRH1HTR1A | |
| SCHEMBL11235122 | 0.74 | DRD2 (0.57) | DRD2DRD4HTR2AHRH1HTR1A | |
| SCHEMBL11247347 | 0.73 | HTR3E (0.51) | DRD2SIGMAR1SLC6A3OPRM1OPRD1 | |
| SCHEMBL11244145 | 0.70 | CYP2D6 (0.57) | DRD2DRD4HTR2AHRH1HTR1A | |
| SCHEMBL11245054 | 0.70 | SLC18A3 (0.43) | DRD2DRD4HTR2AHRH1HTR1A | |
| SCHEMBL10554386 | 0.68 | SLC6A3 (0.60) | DRD2DRD4HTR2AHRH1HTR1A | |
| SCHEMBL9053117 | 0.68 | DRD2 (0.77) | DRD2DRD4HTR2AHRH1HTR1A | |
| Hydrochloric Acid SCHEMBL10557900 | 0.68 | SLC6A3 (0.59) | DRD2DRD4HTR2AHRH1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4366154-A | TRANQUILIZERS; PSYCHOLOGICAL DISORDERS | SANDOZ, INC. (US) | 1982-12-28 | — | — | US | claimed |
| US-4366154-A | TRANQUILIZERS; PSYCHOLOGICAL DISORDERS | SANDOZ, INC. (US) | 1982-12-28 | — | — | US | disclosed |