SCHEMBL11240186

SCHEMBL11240186

O=C(O)Cc1ccc2c(c1)sc1ccc(OCc3ccccc3)cc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 1/20 0.52
FFAR1 O14842 3/20 0.46
MAOB P27338 2/20 0.46
RXRA P19793 1/20 0.46
RXRB P28702 1/20 0.46
RXRG P48443 1/20 0.46
MAOA P21397 1/20 0.46
ALOX5 P09917 3/20 0.46
FFAR4 Q5NUL3 1/20 0.46
P2RY14 Q15391 1/20 0.46
PPARG P37231 2/20 0.45
PPARD Q03181 2/20 0.45
PPARA Q07869 2/20 0.45
TNKS2 Q9H2K2 1/20 0.45
PARP2 Q9UGN5 1/20 0.45
PTPN7 P35236 1/20 0.43
DUSP3 P51452 1/20 0.43
PTPN12 Q05209 1/20 0.43
PTPN22 Q9Y2R2 1/20 0.43
NR4A2 P43354 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3156910 0.83 ALOX5 (0.58) EDNRAMAOBMAOAALOX5TNKS2
SCHEMBL11246657 0.82 AKR1C2 (0.58) PPARGPTPN7DUSP3PTPN12PTPN22
SCHEMBL11232390 0.80 AKR1B1 (0.53) FFAR1RXRARXRB
SCHEMBL11246646 0.79 CA2 (0.49)
Methane SCHEMBL11248449 0.79 AKR1B1 (0.51) RXRARXRB
SCHEMBL28323903 0.77 CYP3A4 (0.49) MAOBMAOAALOX5P2RY14PPARG
SCHEMBL28876964 0.76 CYP1A2 (0.57) EDNRAMAOBMAOAALOX5P2RY14
SCHEMBL11243330 0.76 SLC22A12 (0.45)
SCHEMBL11236099 0.76 CYP1A2 (0.51)
SCHEMBL11439398 0.76 LMNA (0.57) MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4334078-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS HOFFMANN-LA ROCHE INC. (US) 1982-06-08 US disclosed
US-4219657-A USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1980-08-26 US disclosed