Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.30 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263022 | 1.00 | POLB (0.34) | POLBKMT2ASMN1; SMN2L3MBTL1RAF1 | |
| SCHEMBL11249698 | 0.73 | CYP1A2 (0.38) | POLBKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11247962 | 0.72 | GLS (0.40) | POLBKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL11242343 | 0.70 | ADRA2A (0.36) | POLBKMT2ADOT1LALDH1A1MEN1 | |
| SCHEMBL5179498 | 0.69 | ALDH1A1 (0.40) | KMT2AALDH1A1 | |
| SCHEMBL9125705 | 0.68 | KMT2A (0.40) | KMT2AL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL11558226 | 0.68 | POLB (0.68) | POLB | |
| SCHEMBL11247894 | 0.67 | TSHR (0.42) | KMT2AALDH1A1MEN1 | |
| SCHEMBL11241971 | 0.67 | ALDH1A1 (0.41) | POLBKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11559814 | 0.66 | POLB (0.40) | POLBKMT2AL3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4318915-A | Substituted guandines and methods of preparation thereof | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1982-03-09 | — | — | US | claimed |
| US-4318915-A | Substituted guandines and methods of preparation thereof | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1982-03-09 | — | — | US | disclosed |