Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248847 | 0.89 | ITGAL (0.41) | SLC6A9SMN1; SMN2ALDH1A1L3MBTL1GLA | |
| SCHEMBL11258118 | 0.89 | SLC6A9 (0.43) | SLC6A9KDM4ESMN1; SMN2NPY1RNPY2R | |
| SCHEMBL11249100 | 0.84 | HTR1A (0.43) | SLC6A9KDM4EALDH1A1MAPTOPRM1 | |
| Bromide SCHEMBL11248578 | 0.83 | HTR1A (0.43) | SLC6A9KDM4EALDH1A1MAPTOPRM1 | |
| SCHEMBL11248404 | 0.82 | SMN1; SMN2 (0.43) | SLC6A9KDM4ESMN1; SMN2NPY1RNPY2R | |
| SCHEMBL11257928 | 0.80 | ALDH1A1 (0.46) | KDM4ESMN1; SMN2NPY1RNPY2RALDH1A1 | |
| SCHEMBL11255005 | 0.79 | SCN1A (0.41) | KDM4ESMN1; SMN2ALDH1A1MAPTOPRM1 | |
| SCHEMBL11253112 | 0.74 | HTR1A (0.40) | SLC6A9KDM4ESMN1; SMN2NPY1RNPY2R | |
| SCHEMBL11247836 | 0.74 | OPRM1 (0.42) | ALDH1A1OPRM1HTR1AHTR3ACHRNA7 | |
| Bromide SCHEMBL11247256 | 0.73 | HTR1A (0.40) | SLC6A9KDM4ESMN1; SMN2NPY1RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013424-B1 | SPIRO(DIBENZO(B,F)THIEPINE-PIPERIDINES), INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-17 | — | — | EP | disclosed |
| EP-0013424-A1 | Spiro(dibenzo(b,f)thiepine-piperidines), intermediate products for their preparation and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-07-23 | — | — | EP | disclosed |