SCHEMBL11265484

SCHEMBL11265484

O=c1n(-c2ccccc2)cnn1SC(F)(Cl)Cl

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.36
TDP1 Q9NUW8 1/20 0.36
ROCK2 O75116 2/20 0.34
PPARD Q03181 5/20 0.33
PPARA Q07869 5/20 0.33
PPARG P37231 3/20 0.33
HTT P42858 3/20 0.33
SMN1; SMN2 Q16637 4/20 0.32
MITF O75030 2/20 0.32
HCAR1 Q9BXC0 1/20 0.32
LMNA P02545 1/20 0.32
DGAT1 O75907 1/20 0.31
RAB9A P51151 2/20 0.31
MAPT P10636 2/20 0.31
POLB P06746 1/20 0.31
NPC1 O15118 1/20 0.30
S1PR4 O95977 1/20 0.30
THRB P10828 1/20 0.30
XBP1 P17861 1/20 0.30
S1PR1 P21453 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11273409 0.92 ROCK2 (0.41) ROCK2PPARDPPARAPPARGMAPT
SCHEMBL11268398 0.88 ALDH1A1 (0.41) ALDH1A1TDP1ROCK2PPARDPPARA
SCHEMBL11266860 0.87 PPARD (0.35) ROCK2PPARDPPARAPPARGHCAR1
SCHEMBL11270305 0.87 MAPT (0.39) ALDH1A1PPARDPPARAPPARGHTT
SCHEMBL11271704 0.86 HTT (0.51) ALDH1A1PPARDPPARAPPARGHTT
SCHEMBL11276254 0.86 HCAR1 (0.40) ALDH1A1HTTSMN1; SMN2HCAR1POLB
SCHEMBL11273387 0.85 MEN1 (0.38) ALDH1A1PPARDPPARAPPARGSMN1; SMN2
SCHEMBL11279667 0.82 MAPT (0.46) ALDH1A1PPARDPPARAPPARGHTT
SCHEMBL11273757 0.82 CYP11B2 (0.31)
SCHEMBL11270653 0.82 HTT (0.40) PPARDPPARAPPARGHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4350701-A 1-(Trihalomethyl-sulfenyl)-4-aryl-1,2,4-triazolin-5-ones, and process for controlling fungi BASF AKTIENGESELLSCHAFT (DE) 1982-09-21 US disclosed