SCHEMBL1127171

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL15161945	0.88	HTR1A (0.44)	ALDH1A1SMN1; SMN2KDM4EMAPTCYP1A2
	SCHEMBL1989043	0.88	MAPT (0.38)	POLBKDM4EMAPTUSP2
	SCHEMBL1126811	0.88	MAPT (0.36)	POLBKDM4EMAPTLMNAHSD17B10
	SCHEMBL30234914	0.88	POLB (0.45)	POLBALDH1A1SMN1; SMN2KDM4EMAPT
	SCHEMBL1127042	0.88	POLB (0.45)	POLBALDH1A1SMN1; SMN2KDM4EMAPT
	SCHEMBL1126522	0.87	MAPT (0.37)	POLBMAPTCYP3A4LMNA
	SCHEMBL1999344	0.87	MAPT (0.41)	POLBALDH1A1MAPTCYP1A2KMT2A
	SCHEMBL1126883	0.86	SIGMAR1 (0.38)	POLBMAPTDRD2DRD4DRD3
	SCHEMBL1126921	0.86	MAPT (0.37)	POLBMAPTCYP3A4LMNATSHR
	SCHEMBL1126928	0.86	MAPT (0.39)	POLBALDH1A1KDM4EMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.