SCHEMBL1989043

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1999344	0.92	MAPT (0.41)	MAPTPOLBUSP2
	SCHEMBL1126883	0.89	SIGMAR1 (0.38)	MAPTPOLBF10
	SCHEMBL1126921	0.89	MAPT (0.37)	MAPTPOLBF10TP53
	SCHEMBL1126522	0.89	MAPT (0.37)	MAPTPOLBF10CHRM3TP53
	SCHEMBL1126928	0.89	MAPT (0.39)	MAPTPOLBKDM4EF10TP53
	SCHEMBL1127171	0.88	POLB (0.42)	MAPTPOLBKDM4EUSP2
	SCHEMBL1126811	0.87	MAPT (0.36)	MAPTPOLBKDM4EF10CHRM3
	SCHEMBL1126750	0.87	GAA (0.37)	MAPTKDM4ETP53PSMD14USP2
	SCHEMBL1126754	0.85	NPY2R (0.45)	MAPTPOLBKDM4ETP53
	SCHEMBL1994130	0.83	MAPT (0.39)	MAPTPOLBKDM4ETP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.