SCHEMBL1127573

SCHEMBL1127573

Nc1ccc(-c2ncco2)c(F)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 2/20 0.38
ADRA2A P08913 1/20 0.38
ADRA1D P25100 1/20 0.38
ADRA1B P35368 1/20 0.38
KIT P10721 2/20 0.37
CFTR P13569 1/20 0.36
USP9X Q93008 1/20 0.35
BRD4 O60885 1/20 0.35
PIN1 Q13526 1/20 0.35
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
HPGDS O60760 1/20 0.33
ADRA2B P18089 1/20 0.33
RORC P51449 1/20 0.33
ADORA2A P29274 2/20 0.33
ADORA3 P0DMS8 1/20 0.33
ADORA2B P29275 1/20 0.33
ADORA1 P30542 1/20 0.33
GAA P10253 2/20 0.33
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7834048 0.82 ADRA1A (0.48) ADRA1AADRA2AADRA1DADRA1BUSP9X
SCHEMBL8684057 0.79 SMN1; SMN2 (0.51) ADRA1AADRA2AADRA1DADRA1BCFTR
SCHEMBL25286035 0.79 NPC1 (0.40) ADRA1AADRA2AADRA1DADRA1BUSP9X
SCHEMBL22187760 0.79 CTSA (0.44) ADRA1AADRA2AADRA1DADRA1BUSP9X
SCHEMBL30039950 0.78 RAB9A (0.39) CFTRBRD4PIN1NPC1RAB9A
SCHEMBL28498940 0.78 RAB9A (0.39) CFTRBRD4PIN1NPC1RAB9A
SCHEMBL2306346 0.76 SMN1; SMN2 (0.51) CFTRBRD4PIN1NPC1RAB9A
SCHEMBL4408061 0.76 KDM4E (0.43) CFTRBRD4PIN1NPC1RAB9A
SCHEMBL13380088 0.76 AKR1C3 (0.38) ADRA1AADRA2AADRA1DADRA1BUSP9X
SCHEMBL24243097 0.76 ALOX5AP (0.48) ADRA1AADRA2AADRA1DADRA1BCFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220041597-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. 2022-02-10 US disclosed
US-20220041597-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. 2022-02-10 US disclosed
US-20210346356-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. 2021-11-11 US disclosed
US-20210346356-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. 2021-11-11 US disclosed
EP-3902533-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X Forma Therapeutics, Inc. (US) 2021-11-03 EP disclosed
EP-3852792-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X Forma Therapeutics, Inc. (US) 2021-07-28 EP disclosed
WO-2021055668-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2021-03-25 WO disclosed
WO-2021055668-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2021-03-25 WO disclosed
WO-2020191022-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2020-09-24 WO disclosed
WO-2020191022-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2020-09-24 WO disclosed
WO-2020061252-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X FORMA THERAPEUTICS, INC. (US) 2020-03-26 WO disclosed
US-9452168-B2 Pyrrole antifungal agents F2G LTD (GB) 2016-09-27 US disclosed
US-20150238500-A1 PYRROLE ANTIFUNGAL AGENTS F2G LTD (GB) 2015-08-27 US disclosed
US-8993574-B2 Pyrrole antifungal agents F2G LTD (GB) 2015-03-31 US disclosed
EP-2283006-B1 PYRROLE ANTIFUNGAL AGENTS F2G LTD (GB) 2015-02-25 EP disclosed
EP-2626361-B1 Pyrrole antifungal agents F2G LTD (GB) 2014-10-15 EP disclosed
EP-2626361-A1 Pyrrole antifungal agents F2G Limited (GB) 2013-08-14 EP disclosed
US-20110152285-A1 PYRROLE ANTIFUNGAL AGENTS F2G LTD (GB) 2011-06-23 US disclosed
EP-2283006-A1 PYRROLE ANTIFUNGAL AGENTS F2G Limited (GB) 2011-02-16 EP disclosed
WO-2009130481-A1 PYRROLE ANTIFUNGAL AGENTS F2G LTD (GB) 2009-10-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210346356-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X USP9X, RBX1, USP19 ADRA1A 4640/4885ADRA2A 4678/4885ADRA1D 4455/4885
US-20110152285-A1 PYRROLE ANTIFUNGAL AGENTS FOXM1, PYCR1, ARG1 ADRA1A 1021/4885ADRA2A 3510/4885ADRA1D 1146/4885
US-20150238500-A1 PYRROLE ANTIFUNGAL AGENTS FOXM1, PYCR1, ARG1 ADRA1A 1021/4885ADRA2A 3510/4885ADRA1D 1146/4885
US-20220041597-A1 INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X MCL1, HSPA9, USP10 ADRA1A 4793/4885ADRA2A 4817/4885ADRA1D 4295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.