Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | NPBWR1 | P48145 | 11/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11278901 | 0.88 | HTT (0.46) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL11277938 | 0.86 | PTGES (0.52) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL11273766 | 0.85 | SMN1; SMN2 (0.47) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL11281809 | 0.82 | MAPT (0.50) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL11276599 | 0.80 | TLR7 (0.43) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL11273156 | 0.79 | MAPK14 (0.49) | SMN1; SMN2MAPTKMT2ANPBWR1MAPK14 | |
| SCHEMBL11272719 | 0.78 | ITGB1 (0.45) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL11267025 | 0.77 | HTT (0.48) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL11274203 | 0.75 | TLR7 (0.52) | NPC1MAPTALDH1A1KMT2ANPBWR1 | |
| SCHEMBL11276626 | 0.75 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0063413-A1 | 1-Benzoyl-3-(heterocyclic)ureas, compositions, and insecticidal method | ELI LILLY AND COMPANY (US) | 1982-10-27 | — | — | EP | claimed |
| US-4366155-A | 1-Benzoyl-3-(6-oxopyridazinyl)ureas, compositions, and insecticidal method | ELI LILLY AND COMPANY (US) | 1982-12-28 | — | — | US | disclosed |
| EP-0063413-A1 | 1-Benzoyl-3-(heterocyclic)ureas, compositions, and insecticidal method | ELI LILLY AND COMPANY (US) | 1982-10-27 | — | — | EP | disclosed |