SCHEMBL11278799

SCHEMBL11278799

NC(=O)NC(=O)c1nc2cc(Cl)c(Cl)cc2nc1O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 1/20 0.40
MMP2 P08253 1/20 0.40
MMP3 P08254 1/20 0.40
GRIN2D O15399 3/20 0.36
GRIN3B O60391 3/20 0.36
GRIA1 P42261 3/20 0.36
GRIA2 P42262 3/20 0.36
GRIA3 P42263 3/20 0.36
GRIA4 P48058 3/20 0.36
GRIN1 Q05586 3/20 0.36
GRIN2A Q12879 3/20 0.36
GRIN2B Q13224 3/20 0.36
GRIN2C Q14957 3/20 0.36
GRIN3A Q8TCU5 3/20 0.36
LMNA P02545 2/20 0.36
GRIK1 P39086 2/20 0.36
GRIK2 Q13002 2/20 0.36
GRIK3 Q13003 2/20 0.36
GRIK4 Q16099 2/20 0.36
GRIK5 Q16478 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2548424 0.83 MMP1 (0.42) MMP1MMP2MMP3GRIN2DGRIN3B
SCHEMBL9704201 0.80 APEX1 (0.39) MMP1MMP2MMP3GRIN2DGRIN3B
SCHEMBL9705662 0.76 RAB9A (0.44) TP53TSHRHSD17B10KDM4EALDH1A1
6,7-Dichloro-3-Hydroxy-2-Quinoxalinecarboxylic Acid SCHEMBL4287210 0.75 GRIN2D (0.53) MMP1MMP2MMP3GRIN2DGRIN3B
SCHEMBL9705741 0.75 GRIN2D (0.65) GRIN2DGRIN3BGRIA1GRIA2GRIA3
2,3-Dihydroxy-6,7-Dichloroquinoxaline SCHEMBL1259521 0.70 MMP1 (0.50) MMP1MMP2MMP3GLP1RCYP3A4
SCHEMBL2552563 0.67 GLP1R (0.66) GLP1RCYP1A2TP53HSD17B10KDM4E
SCHEMBL22733357 0.65 KEAP1 (0.37) LMNACYP1A2KDM4EALDH1A1BCAT2
SCHEMBL15328038 0.63 BCAT2 (0.65) LMNATSHRKDM4EHPGDKMT2A
SCHEMBL9703955 0.62 HRH4 (0.43) MMP1MMP2MMP3GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4358307-A PREFERENTIAL CONTROLLING OF MONOCOTYLEDONS IN CROPS ICI AUSTRALIA LIMITED (AU) 1982-11-09 US disclosed
EP-0026622-A2 Quinoxalinylaminophenoxyalkane carboxylic acid derivatives, their preparation, their use as herbicides and intermediates ICI AUSTRALIA LIMITED (AU) 1981-04-08 EP disclosed