Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 8/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9672986 | 0.77 | NOTUM (0.32) | NOTUMPOLBNSD2GRK2CASP6 | |
| SCHEMBL7109188 | 0.74 | NPC1 (0.43) | NOTUMNPC1KMT2ARAB9AMEN1 | |
| SCHEMBL3988622 | 0.70 | NOTUM (0.38) | NOTUMKMT2AMEN1POLBNSD2 | |
| SCHEMBL7963893 | 0.70 | PTGS1 (0.43) | NPC1KMT2ARAB9AMEN1POLB | |
| SCHEMBL25282089 | 0.70 | KMT2A (0.45) | NPC1KMT2ARAB9AMEN1ALDH1A1 | |
| SCHEMBL5056802 | 0.69 | NPC1 (0.60) | NPC1KMT2ARAB9AMEN1POLB | |
| SCHEMBL7679127 | 0.69 | KMT2A (0.41) | NPC1KMT2ARAB9AMEN1POLB | |
| SCHEMBL9748012 | 0.68 | ALDH1A1 (0.40) | NPC1KMT2ARAB9AMEN1POLB | |
| SCHEMBL4739140 | 0.66 | KMT2A (0.45) | NPC1KMT2ARAB9AMEN1POLB | |
| SCHEMBL31154491 | 0.66 | FPR2 (0.39) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4363918-A | Method of preparing 1-alkyl-3-carboxy-1H pyrrole-2-acetic acids | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-14 | — | — | US | claimed |
| US-4363918-A | Method of preparing 1-alkyl-3-carboxy-1H pyrrole-2-acetic acids | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-14 | — | — | US | disclosed |
| US-4363918-A | Method of preparing 1-alkyl-3-carboxy-1H pyrrole-2-acetic acids | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-14 | — | — | US | disclosed |
| US-4363918-A | Method of preparing 1-alkyl-3-carboxy-1H pyrrole-2-acetic acids | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-14 | — | — | US | disclosed |