Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 3/20 | 0.65 |
| ▸ | MMP1 | P03956 | 3/20 | 0.65 |
| ▸ | MMP2 | P08253 | 2/20 | 0.65 |
| ▸ | MMP14 | P50281 | 2/20 | 0.65 |
| ▸ | MMP13 | P45452 | 2/20 | 0.65 |
| ▸ | MMP9 | P14780 | 1/20 | 0.65 |
| ▸ | MMP16 | P51512 | 1/20 | 0.65 |
| ▸ | DAGLA | Q9Y4D2 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133744 | 0.91 | MMP8 (0.81) | MMP8MMP1MMP2MMP14MMP13 | |
| SCHEMBL1133911 | 0.88 | MMP2 (0.82) | MMP8MMP1MMP2MMP14MMP13 | |
| SCHEMBL1133895 | 0.85 | MMP2 (0.69) | MMP8MMP1MMP2MMP14MMP13 | |
| SCHEMBL1133756 | 0.85 | MMP2 (0.65) | MMP8MMP1MMP2MMP14MMP13 | |
| SCHEMBL15720060 | 0.81 | KMT2A (0.57) | MMP8MMP1MMP13SMN1; SMN2LMNA | |
| SCHEMBL2195059 | 0.81 | SMN1; SMN2 (0.49) | MMP8MMP1MMP2MMP14MMP13 | |
| SCHEMBL16894098 | 0.80 | MMP1 (0.72) | MMP8MMP1MMP13SMN1; SMN2NPC1 | |
| SCHEMBL1133742 | 0.80 | FFAR1 (0.51) | MMP8MMP1MMP2MMP14MMP13 | |
| SCHEMBL3503903 | 0.80 | KEAP1 (0.76) | MMP8MMP1MMP2MMP14MMP13 | |
| SCHEMBL1133828 | 0.79 | MMP2 (1.00) | MMP8MMP1MMP2MMP14MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524194-B2 | Radiolabelled MMP selective compounds | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2013-09-03 | — | — | US | disclosed |
| US-20110171133-A1 | RADIOLABELLED MMP SELECTIVE COMPOUNDS | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2011-07-14 | — | — | US | disclosed |
| EP-2285759-A1 | RADIOLABELLED MMP SELECTIVE COMPOUNDS | Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009139633-A1 | RADIOLABELLED MMP SELECTIVE COMPOUNDS | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009139634-A1 | RADIOLABELLED MMP SELECTIVE COMPOUNDS | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2009-11-19 | — | — | WO | disclosed |
| EP-2119690-A1 | Radiolabelled MMP selective compounds | Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) | 2009-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110171133-A1 | RADIOLABELLED MMP SELECTIVE COMPOUNDS | MMP1, MMP3, MMP9 | MMP8 31/4885MMP1 1/4885MMP2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.