Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9972493 | 0.85 | KEAP1 (0.62) | KMT2AMEN1ALDH1A1KEAP1NFE2L2 | |
| SCHEMBL5285705 | 0.85 | MAPK1 (0.63) | KMT2AMEN1ALDH1A1KEAP1NFE2L2 | |
| SCHEMBL7461410 | 0.84 | TAS2R14 (0.61) | KEAP1NFE2L2TAS2R14MMP1MMP7 | |
| SCHEMBL3246445 | 0.84 | ALDH1A1 (0.73) | KMT2AMEN1ALDH1A1TSHRMAPK1 | |
| SCHEMBL16894098 | 0.83 | MMP1 (0.72) | KMT2AMEN1KEAP1NFE2L2POLB | |
| SCHEMBL16894270 | 0.82 | TAS2R14 (0.51) | KMT2AMEN1KEAP1NFE2L2MAPK1 | |
| SCHEMBL1133869 | 0.81 | MMP8 (0.65) | KEAP1NFE2L2LMNAHTTSMN1; SMN2 | |
| SCHEMBL16894212 | 0.81 | MAPK1 (0.67) | ALDH1A1KEAP1NFE2L2MAPK1LMNA | |
| SCHEMBL22252112 | 0.80 | KEAP1 (0.69) | KMT2AKEAP1NFE2L2TAS2R14 | |
| SCHEMBL6501947 | 0.80 | KMT2A (0.63) | KMT2AMEN1ALDH1A1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |
| US-9580411-B2 | Substituted sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-9359337-B2 | Acetamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-9359337-B2 | Acetamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-9359337-B2 | Acetamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |
| EP-2920158-A1 | NOVEL ACETAMIDE DERIVATIVES AS TRP CHANNEL ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2015-09-23 | — | — | EP | disclosed |
| US-20150246906-A1 | NOVEL ACETAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-03 | — | — | US | disclosed |
| US-20150246906-A1 | NOVEL ACETAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-03 | — | — | US | disclosed |
| US-20150246906-A1 | NOVEL ACETAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-03 | — | — | US | disclosed |
| EP-2900642-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2015-08-05 | — | — | EP | disclosed |
| US-20150197509-A1 | SUBSTITUTED SULFONAMIDE SOLUTIONS | GENENTECH, INC. (US) | 2015-07-16 | — | — | US | disclosed |
| WO-2014076038-A1 | NOVEL ACETAMIDE DERIVATIVES AS TRP CHANNEL ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150197509-A1 | SUBSTITUTED SULFONAMIDE SOLUTIONS | TRPA1, TRPV1, TRPV5 | KMT2A 2838/4885MEN1 3909/4885ALDH1A1 949/4885 |
| US-20150246906-A1 | NOVEL ACETAMIDE DERIVATIVES | ADCY4, ADCY3, ADCY1 | KMT2A 1642/4885MEN1 1390/4885ALDH1A1 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.