Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 4/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1134049 | 0.87 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2F2PRSS1PRSS2 | |
| SCHEMBL1133836 | 0.87 | MMP13 (0.46) | ALDH1A1SMN1; SMN2F2PRSS1PRSS2 | |
| SCHEMBL1133821 | 0.77 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2MMP2MMP9POLB | |
| SCHEMBL1133818 | 0.72 | MMP13 (0.44) | ALDH1A1SMN1; SMN2MMP2MMP9POLB | |
| SCHEMBL15895195 | 0.68 | PTPN1 (0.50) | SMN1; SMN2POLBLMNAMEN1GAA | |
| SCHEMBL25564566 | 0.65 | MMP2 (0.50) | ALDH1A1SMN1; SMN2F2PRSS1PRSS2 | |
| SCHEMBL1133773 | 0.65 | LMNA (0.59) | SMN1; SMN2MMP2MMP9MMP13LMNA | |
| SCHEMBL3669592 | 0.65 | HTT (0.55) | ALDH1A1SMN1; SMN2MMP2MMP9POLB | |
| SCHEMBL16447010 | 0.65 | MTNR1A (0.46) | SMN1; SMN2LMNA | |
| SCHEMBL2194247 | 0.64 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2MMP2MMP9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285759-A1 | RADIOLABELLED MMP SELECTIVE COMPOUNDS | Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009139634-A1 | RADIOLABELLED MMP SELECTIVE COMPOUNDS | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009139633-A1 | RADIOLABELLED MMP SELECTIVE COMPOUNDS | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2009-11-19 | — | — | WO | disclosed |