SCHEMBL1134087

SCHEMBL1134087

COc1cccc(N(C)c2ccccc2)c1

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 9/20 0.60
MTNR1B P49286 9/20 0.60
CA4 P22748 1/20 0.50
CSF1R P07333 2/20 0.49
HSD17B2 P37059 3/20 0.48
HSD17B1 P14061 2/20 0.48
ACHE P22303 1/20 0.47
SLC6A2 P23975 1/20 0.47
SLC6A4 P31645 1/20 0.47
MAOB P27338 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1134082 0.94 MTNR1A (0.61) MTNR1AMTNR1BHSD17B2HSD17B1ACHE
SCHEMBL30054343 0.94 MTNR1A (0.61) MTNR1AMTNR1BHSD17B2HSD17B1ACHE
SCHEMBL12047760 0.93 MTNR1A (0.58) MTNR1AMTNR1BCA4CSF1RHSD17B2
SCHEMBL13241208 0.89 HSD17B2 (0.52) MTNR1AMTNR1BCSF1RHSD17B2HSD17B1
SCHEMBL9005151 0.89 MTNR1A (0.61) MTNR1AMTNR1BHSD17B2HSD17B1ACHE
SCHEMBL12048278 0.88 MTNR1A (0.55) MTNR1AMTNR1BCSF1RHSD17B2HSD17B1
SCHEMBL9479766 0.87 MTNR1B (0.64) MTNR1AMTNR1B
SCHEMBL12048224 0.87 MTNR1A (0.54) MTNR1AMTNR1BCSF1RHSD17B2HSD17B1
SCHEMBL12048630 0.87 MTNR1A (0.53) MTNR1AMTNR1BHSD17B2HSD17B1
SCHEMBL12048140 0.87 MTNR1A (0.53) MTNR1AMTNR1BHSD17B2HSD17B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4137551-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE THEREOF Beijing Summer Sprout Technology Co., Ltd. (CN) 2023-02-22 EP disclosed
US-10940470-B2 Ylide-functionalised phosphanes for use in metal complexes and homogeneous catalysis UMICORE AG & CO. KG (DE) 2021-03-09 US disclosed
US-20200164354-A1 YLIDE-FUNCTIONALISED PHOSPHANES FOR USE IN METAL COMPLEXES AND HOMOGENEOUS CATALYSIS UMICORE AG & CO. KG (DE) 2020-05-28 US disclosed
WO-2019030304-A1 YLIDE-FUNCTIONALISED PHOSPHANES FOR USE IN METAL COMPLEXES AND HOMOGENEOUS CATALYSIS RUHR-UNIVERSITäT BOCHUM (DE) 2019-02-14 WO disclosed
EP-3013787-B1 TRANSITION-METAL-FREE N-ARYLATION OF TERTIARY AMINES USING ARYNES COUNCIL SCIENT IND RES (IN) 2017-08-02 EP disclosed
EP-3013787-B1 TRANSITION-METAL-FREE N-ARYLATION OF TERTIARY AMINES USING ARYNES COUNCIL SCIENT IND RES (IN) 2017-08-02 EP disclosed
US-9650329-B2 Transition-metal-free N-arylation of tertiary amines using arynes COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2017-05-16 US disclosed
US-9650329-B2 Transition-metal-free N-arylation of tertiary amines using arynes COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2017-05-16 US disclosed
US-9650329-B2 Transition-metal-free N-arylation of tertiary amines using arynes COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2017-05-16 US disclosed
US-20160137587-A1 TRANSITION-METAL-FREE N-ARYLATION OF TERTIARY AMINES USING ARYNES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-05-19 US disclosed
US-20080008907-A1 Compound And Organic Light Emitting Device Using The Same LG CHEM, LTD. (PROSECUTION) (KR) 2008-01-10 US disclosed
US-20080008907-A1 Compound And Organic Light Emitting Device Using The Same LG CHEM, LTD. (PROSECUTION) (KR) 2008-01-10 US disclosed
US-20070292715-A1 New Compound and Organic Light Emitting Device Using the Same LG CHEM, LTD. (KR) 2007-12-20 US disclosed
US-20070292715-A1 New Compound and Organic Light Emitting Device Using the Same LG CHEM, LTD. (KR) 2007-12-20 US disclosed
EP-0977087-B1 Electrophotographic apparatus CANON KK (JP) 2007-12-12 EP disclosed
US-20070262706-A1 New Compound and Organic Light Emitting Device Using the Same LG CHEM, LTD. (KR) 2007-11-15 US disclosed
US-20070262706-A1 New Compound and Organic Light Emitting Device Using the Same LG CHEM, LTD. (KR) 2007-11-15 US disclosed
US-20070247059-A1 Compound and Organic Light Emitting Device Using the Same LG CHEM, LTD. (KR) 2007-10-25 US disclosed
US-20070247059-A1 Compound and Organic Light Emitting Device Using the Same LG CHEM, LTD. (KR) 2007-10-25 US disclosed
US-4115413-A ACID FREE BAYER AKTIENGESELLSCHAFT (DE) 1978-09-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160137587-A1 TRANSITION-METAL-FREE N-ARYLATION OF TERTIARY AMINES USING ARYNES CDK6, NEK6, MCM6 MTNR1A 610/4885MTNR1B 696/4885CA4 1702/4885
US-20070247059-A1 Compound and Organic Light Emitting Device Using the Same PPOX, CRY1, CRY2 MTNR1A 2693/4885MTNR1B 2739/4885CA4 3963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.