SCHEMBL11348242

SCHEMBL11348242

O=C(Cl)c1ccc(-c2cc3ccccc3[nH]2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.63
KDM4E B2RXH2 5/20 0.63
MAPT P10636 5/20 0.63
RAB9A P51151 4/20 0.63
MEN1 O00255 4/20 0.63
KMT2A Q03164 4/20 0.63
CASP3 P42574 3/20 0.63
SENP8 Q96LD8 3/20 0.63
SENP7 Q9BQF6 3/20 0.63
SENP6 Q9GZR1 3/20 0.63
ALDH1A1 P00352 3/20 0.63
HPGD P15428 3/20 0.63
CYP1A2 P05177 1/20 0.63
CYP2C9 P11712 1/20 0.63
CYP2C19 P33261 1/20 0.63
CA12 O43570 1/20 0.55
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
CA9 Q16790 1/20 0.55
F2 P00734 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7941122 0.85 CASP3 (0.71) NPC1KDM4EMAPTRAB9AMEN1
SCHEMBL4793005 0.84 RIPK1 (0.61) NPC1KDM4EMAPTRAB9AMEN1
SCHEMBL22493564 0.84 NPC1 (0.61) NPC1KDM4EMAPTRAB9AMEN1
SCHEMBL5053299 0.82 NPC1 (0.87) NPC1KDM4EMAPTRAB9AMEN1
SCHEMBL28416625 0.80 NPC1 (0.83) NPC1KDM4EMAPTRAB9AMEN1
SCHEMBL28580125 0.80 RAB9A (0.61) NPC1KDM4EMAPTRAB9AMEN1
SCHEMBL11339106 0.79 CHEK2 (0.48) NPC1KDM4EMAPTRAB9AMEN1
SCHEMBL11335654 0.79 NPC1 (0.56) NPC1KDM4EMAPTRAB9AMEN1
SCHEMBL11331767 0.78 CASP3 (0.47) NPC1KDM4EMAPTRAB9AMEN1
SCHEMBL29620661 0.78 KMT2A (1.00) NPC1KDM4EMAPTRAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4308194-A Heterocyclic benzoate ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1981-12-29 US disclosed
US-4075220-A FOR POLYMERS EASTMAN KODAK COMPANY (US) 1978-02-21 US disclosed
US-4065427-A Polychromophoric heterocyclic ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1977-12-27 US disclosed
US-4000148-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-12-28 US disclosed
US-3957813-A BENZOXAZOLYL PHENYL AROMATIC ESTER COMPOUNDS AND THEIR USE AS ULTRAVIOLET STABILIZERS IN ORGANIC COMPOSITIONS EASTMAN KODAK COMPANY (US) 1976-05-18 US disclosed