Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | CASP3 | P42574 | 3/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7941122 | 0.85 | CASP3 (0.71) | NPC1RAB9AMAPTCASP3SENP8 | |
| SCHEMBL4793005 | 0.84 | RIPK1 (0.61) | NPC1RAB9AMAPTCASP3SENP8 | |
| SCHEMBL11348242 | 0.84 | NPC1 (0.63) | NPC1RAB9AMAPTCASP3SENP8 | |
| SCHEMBL28580125 | 0.83 | RAB9A (0.61) | NPC1RAB9AMAPTCASP3SENP8 | |
| SCHEMBL23717137 | 0.83 | F2 (0.64) | NPC1RAB9AMAPTCASP3SENP8 | |
| SCHEMBL5053299 | 0.82 | NPC1 (0.87) | NPC1RAB9AMAPTCASP3SENP8 | |
| SCHEMBL28416625 | 0.80 | NPC1 (0.83) | NPC1RAB9AMAPTCASP3SENP8 | |
| SCHEMBL11728172 | 0.80 | ITK (0.60) | NPC1RAB9AMAPTCASP3SENP8 | |
| SCHEMBL11725233 | 0.80 | KDM4E (0.66) | NPC1RAB9AMAPTCASP3SENP8 | |
| SCHEMBL22926252 | 0.80 | KDR (0.54) | MAPTKDM4EHPGDEGFRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198478-A1 | SEROTONIN 5-HT2B INHIBITORY COMPOUNDS | ZOETIS SERVICES LLC (US) | 2020-10-01 | — | — | WO | disclosed |