Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11292078 | 0.98 | PGR (0.33) | PGRPDE7AAKR1C1 | |
| SCHEMBL11293531 | 0.91 | THRB (0.31) | — | |
| SCHEMBL14307528 | 0.80 | GRIN2B (0.39) | ALDH1A1 | |
| SCHEMBL14307796 | 0.77 | OPRL1 (0.51) | — | |
| SCHEMBL11290237 | 0.74 | PGR (0.35) | PGRPDE7AALDH1A1HDAC4 | |
| SCHEMBL14307524 | 0.72 | HPGD (0.35) | — | |
| SCHEMBL11295881 | 0.72 | PGR (0.33) | PGRALDH1A1AKR1C1HDAC4 | |
| SCHEMBL11294191 | 0.71 | ALDH1A1 (0.33) | PGRALDH1A1 | |
| SCHEMBL11544758 | 0.68 | SLC6A3 (0.42) | — | |
| SCHEMBL11289808 | 0.68 | HDAC4 (0.37) | ALDH1A1AKR1C1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000825-B1 | GEMINALLY DISUBSTITUTED INDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Kabi AB (SE) | 1982-04-14 | — | — | EP | disclosed |
| US-4218472-A | USED AS DECONGESANT, HYPOTENSIVE AGENT, VASOCONSTRICTOR, ANTI-RESERPINE AGENT, TREATING INCONTINENCE | AB KABI (SE) | 1980-08-19 | — | — | US | disclosed |
| EP-0000825-A1 | Geminally disubstituted indene derivatives, processes for their preparation and pharmaceutical compositions containing them | Kabi AB (SE) | 1979-02-21 | — | — | EP | disclosed |