SCHEMBL1140280

SCHEMBL1140280

O=[N+]([O-])c1ccc(C(=NO)c2ccccc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 2/20 0.65
CES2 O00748 1/20 0.65
TDP1 Q9NUW8 1/20 0.55
POLB P06746 2/20 0.54
MAPK1 P28482 1/20 0.54
ALDH1A1 P00352 5/20 0.54
LMNA P02545 2/20 0.54
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
NPC1 O15118 1/20 0.51
MITF O75030 1/20 0.51
RAB9A P51151 1/20 0.51
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
SRD5A2 P31213 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.49
BCHE P06276 1/20 0.49
MAOB P27338 1/20 0.49
CYP1B1 Q16678 1/20 0.49
CRHBP P24387 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29420172 1.00 CES1 (0.65) CES1CES2TDP1POLBMAPK1
SCHEMBL16690236 0.95 POLB (0.63) CES1CES2TDP1POLBMAPK1
SCHEMBL7353197 0.92 CES1 (0.59) CES1CES2TDP1POLBMAPK1
SCHEMBL12418538 0.84 ACHE (0.64) CES1CES2TDP1POLBMAPK1
SCHEMBL7095150 0.84 CES1 (0.62) CES1CES2TDP1POLBMAPK1
SCHEMBL13029991 0.84 ACHE (0.64) CES1CES2TDP1POLBMAPK1
SCHEMBL27578404 0.81 POLB (0.51) CES1CES2TDP1POLBMAPK1
SCHEMBL9670443 0.80 CES1 (0.74) CES1CES2TDP1POLBMAPK1
SCHEMBL28930611 0.80 CES1 (0.74) CES1CES2TDP1POLBMAPK1
SCHEMBL28949248 0.80 CES1 (0.74) CES1CES2TDP1POLBMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 264 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12577200-B2 High-throughput method to rapidly add chemical moieties to a small molecule library MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2026-03-17 US claimed
US-20220089537-A1 HIGH-THROUGHPUT METHOD TO RAPIDLY ADD CHEMICAL MOIETIES TO A SMALL MOLECULE LIBRARY MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2022-03-24 US claimed
WO-2022060459-A1 HIGH-THROUGHPUT METHOD TO RAPIDLY ADD CHEMICAL MOIETIES TO A SMALL MOLECULE LIBRARY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2022-03-24 WO claimed
US-20210163541-A1 Method for Preparing PNA Oligomer SEASUNBIO MATERIALS (KR) 2021-06-03 US claimed
US-20060167224-A1 Novel functional peptide nucleic acid and process for producing the same CREDIA JAPAN CO., LTD. (JP) 2006-07-27 US claimed
EP-1614750-A1 NOVEL FUNCTIONAL PEPTIDE NUCLEIC ACID AND PROCESS FOR PRODUCING THE SAME Credia Japan Co., Ltd. (JP) 2006-01-11 EP claimed
EP-1098659-A4 LIBRARIES OF POLYHYDROXAMATES AND THEIR ANALOGS METAPHORE INC (US) 2004-11-24 EP claimed
EP-1098659-A2 LIBRARIES OF POLYHYDROXAMATES AND THEIR ANALOGS Metaphore, Inc. (US) 2001-05-16 EP claimed
WO-2000004868-A2 LIBRARIES OF POLYHYDROXAMATES AND THEIR ANALOGS METAPHORE, INC. (US) 2000-02-03 WO claimed
US-12629683-B2 Oligonucleotide encoded chemical libraries Plexium, Inc. (US) 2026-05-19 US disclosed
US-12577702-B2 Oligonucleotide encoded chemical libraries, related systems, devices, and methods for detecting, analyzing, quantifying, and testing biologics/genetics Plexium, Inc. (US) 2026-03-17 US disclosed
US-12577200-B2 High-throughput method to rapidly add chemical moieties to a small molecule library MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2026-03-17 US disclosed
US-12030057-B2 Oligonucleotide encoded chemical libraries Plexium, Inc. (US) 2024-07-09 US disclosed
US-20230234065-A1 OLIGONUCLEOTIDE ENCODED CHEMICAL LIBRARIES Plexium, Inc. 2023-07-27 US disclosed
EP-0151166-A4 NOVEL PEPTIDE HORMONES WITH CALCITONIN-LIKE ACTIVITY. UNIVERSITY PATENTS INC (US) 1988-09-28 EP disclosed
US-4663309-A Novel peptide hormones with calcitonin-like activity UNIVERSITY PATENTS, INC. (US) 1987-05-05 US disclosed
EP-0151166-A1 NOVEL PEPTIDE HORMONES WITH CALCITONIN-LIKE ACTIVITY Kaiser, Bonnie L. (US) 1985-08-14 EP disclosed
EP-0132441-A1 ANTIBACTERIAL PEPTIDES UNIVERSITY PATENTS, INC. (US) 1985-02-06 EP disclosed
WO-1985000165-A1 NOVEL PEPTIDE HORMONES WITH CALCITONIN-LIKE ACTIVITY UNIVERSITY PATENTS, INCORPORATED (US) 1985-01-17 WO disclosed
WO-1984002905-A1 ANTIBACTERIAL PEPTIDES UNIVERSITY PATENTS INC (US) 1984-08-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210163541-A1 Method for Preparing PNA Oligomer NCL, NOD1, POLI CES1 3834/4885CES2 4289/4885TDP1 775/4885
US-12629683-B2 Oligonucleotide encoded chemical libraries POLL, PCNA, POLM CES1 3979/4885CES2 3864/4885TDP1 193/4885
US-20220089537-A1 HIGH-THROUGHPUT METHOD TO RAPIDLY ADD CHEMICAL MOIETIES TO A SMALL MOLECULE LIBRARY PDE8B, ACP1, BLVRB CES1 1167/4885CES2 174/4885TDP1 2309/4885
US-20060167224-A1 Novel functional peptide nucleic acid and process for producing the same RNGTT, ADAR, PAM CES1 4232/4885CES2 4484/4885TDP1 329/4885
US-12577200-B2 High-throughput method to rapidly add chemical moieties to a small molecule library CBR3, CBR1, NR2E3 CES1 436/4885CES2 133/4885TDP1 4391/4885
US-12577702-B2 Oligonucleotide encoded chemical libraries, related systems, devices, and methods for detecting, analyzing, quantifying, and testing biologics/genetics RNGTT, TNFSF11, PCNA CES1 795/4885CES2 1139/4885TDP1 555/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.