Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | PPOX | P50336 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LIPE | Q05469 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | XBP1 | P17861 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11455998 | 0.98 | KMT2A (0.56) | KMT2AMEN1TDP1TTRPPOX | |
| SCHEMBL10452504 | 0.91 | KMT2A (0.69) | KMT2AMEN1TDP1TTRPPOX | |
| SCHEMBL10775218 | 0.90 | SMN1; SMN2 (0.58) | KMT2AMEN1TDP1TTRPPOX | |
| SCHEMBL11455024 | 0.88 | KMT2A (0.61) | KMT2AMEN1TDP1TTRPPOX | |
| SCHEMBL10848703 | 0.86 | RAB9A (0.56) | KMT2AMEN1TDP1TTRPPOX | |
| SCHEMBL11153730 | 0.85 | RAB9A (0.62) | KMT2AMEN1TDP1TTRPPOX | |
| SCHEMBL11005246 | 0.84 | SMN1; SMN2 (0.51) | KMT2AMEN1TDP1TTRPPOX | |
| SCHEMBL11220963 | 0.84 | LMNA (0.52) | KMT2AMEN1TDP1TTRPPOX | |
| SCHEMBL9438262 | 0.83 | RAB9A (0.59) | KMT2AMEN1TDP1TTRPPOX | |
| SCHEMBL11016710 | 0.83 | CYP1A2 (0.54) | KMT2AMEN1TDP1TTRPPOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4235621-A | 2-Substituted phenoxy-3-chloro-5-trifluoromethyl pyridine useful as a herbicide | ISHIHARA SANGYO KAISHA LTD. (JP) | 1980-11-25 | — | — | US | disclosed |