Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 3/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.52 |
| ▸ | HTR1D | P28221 | 7/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11463974 | 0.85 | HTR2A (0.65) | KDM4EHTR1BHTR1AHTR2A | |
| SCHEMBL11616457 | 0.83 | TRPM8 (0.50) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL32669329 | 0.82 | TRPM8 (0.67) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| Hydrochloric Acid SCHEMBL11463692 | 0.81 | HTR7 (0.54) | MAPTHTR1DSLC6A4HTR1BHTR1A | |
| SCHEMBL11479098 | 0.80 | HTR6 (0.49) | TRPM8MAPTHTR1DSLC6A4HTR1B | |
| SCHEMBL11558795 | 0.80 | HTR1D (0.47) | MAPTHTR1DHTR1BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11462601 | 0.80 | HTR1A (0.56) | TRPM8HTR1DSLC6A4HTR1BHTR1A | |
| Hydrochloric Acid SCHEMBL11462927 | 0.80 | HTR6 (0.49) | TRPM8MAPTHTR1DSLC6A4HTR1B | |
| SCHEMBL11738116 | 0.79 | HTR6 (0.56) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL11554436 | 0.77 | NQO2 (0.45) | KDM4EHTR1DSLC6A4HTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4242347-A | Hypotensive indolylalkylpiperidyl guanidines and isoureas | CIBA-GEIGY CORPORATION (US) | 1980-12-30 | — | — | US | disclosed |
| US-4147786-A | HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1979-04-03 | — | — | US | disclosed |