Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 13/20 | 0.74 |
| ▸ | MAPT | P10636 | 9/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.74 |
| ▸ | POLB | P06746 | 4/20 | 0.74 |
| ▸ | PKM | P14618 | 3/20 | 0.74 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.63 |
| ▸ | PGR | P06401 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | APEX1 | P27695 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefuracetime SCHEMBL11260426 | 0.92 | TDP1 (0.87) | TDP1MAPTHSD17B10POLBPKM | |
| Cefuracetime SCHEMBL11609526 | 0.92 | TDP1 (0.87) | TDP1MAPTHSD17B10POLBPKM | |
| Cefuracetime SCHEMBL11254696 | 0.92 | TDP1 (0.87) | TDP1MAPTHSD17B10POLBPKM | |
| SCHEMBL11471266 | 0.92 | TDP1 (0.84) | TDP1MAPTHSD17B10POLBPKM | |
| SCHEMBL11612739 | 0.92 | TDP1 (0.74) | TDP1MAPTHSD17B10POLBPKM | |
| SCHEMBL11468458 | 0.92 | TDP1 (0.74) | TDP1MAPTHSD17B10POLBPKM | |
| SCHEMBL11611525 | 0.90 | TDP1 (0.73) | TDP1MAPTHSD17B10POLBPKM | |
| SCHEMBL11548881 | 0.89 | TDP1 (0.69) | TDP1MAPTHSD17B10POLBPKM | |
| SCHEMBL11471273 | 0.88 | CTDSP1 (0.69) | TDP1MAPTHSD17B10POLBPKM | |
| SCHEMBL11470150 | 0.87 | TDP1 (0.63) | TDP1MAPTHSD17B10POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4208517-A | Caphalosporin compounds having at position-7 an α-etherified hydroxyiminoarylacetamido group | GLAXO OPERATIONS UK LIMITED (GB) | 1980-06-17 | — | — | US | disclosed |